1289386-60-2

Basic information

• Product Name: (2-Bromo-pyridin-4-ylmethyl)-isopropyl-amine
• Synonyms: (2-Bromo-pyridin-4-ylmethyl)-isopropyl-amine;2-Bromo-N-(1-methylethyl)-4-pyridinemethanamine;N-[(2-Bromopyridin-4-yl)methyl]propan-2-amine
• CAS NO: 1289386-60-2
• Molecular Formula: C9H13BrN2
• Molecular Weight: 229
• Mol File: 1289386-60-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.317
• CAS DataBase Reference: (2-Bromo-pyridin-4-ylmethyl)-isopropyl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Bromo-pyridin-4-ylmethyl)-isopropyl-amine(1289386-60-2)
• EPA Substance Registry System: (2-Bromo-pyridin-4-ylmethyl)-isopropyl-amine(1289386-60-2)

Safety Data

• Hazardous Substances Data: 1289386-60-2(Hazardous Substances Data)

Usage

General Description

(2-Bromo-pyridin-4-ylmethyl)-isopropyl-amine is an organic compound with the chemical formula C9H13BrN2. It is a secondary amine and contains a bromine atom and a pyridine ring in its structure. (2-Bromo-pyridin-4-ylmethyl)-isopropyl-amine is used in organic synthesis as a building block for the preparation of various pharmaceuticals, agrochemicals, and other fine chemicals. The isopropyl group and the amine functionality make it a versatile intermediate for the synthesis of complex organic molecules. It is also used as a reagent in chemical research and can be used in the production of specialty chemicals and other industrial applications.

Upstream product

• 118289-17-1 2-bromopyridine-4-carboxaldehyde 
• 75-31-0 isopropylamine 

Downstream Products

• 1366407-06-8 N-{[2-(4-Fluorophenyl)pyridin-4-yl]methyl}propan-2-amine 
• 1366404-68-3 N-{[2-(3-fluorophenyl)pyridin-4-yl]methyl}-1-methyl-N-(propan-2-yl)-1H-imidazole-4-carboxamide 
• 1366404-54-7 1-methyl-N-[(2-phenylpyridin-4-yl)methyl]-N-(propan-2-yl)-1H-imidazole-4-carboxamide 
• 1365879-47-5 N-[(2-bromopyridin-4-yl)methyl]-1-methyl-N-(propan-2-yl)-1H-imidazole-4-carboxamide 

Relevant articles and documents

Identification of 1-methyl-N-(propan-2-yl)-N-({2-[4-(trifluoromethoxy)-phenyl]pyridin-4-yl}methyl)-1H-imidazole-4-carboxamide as a potent and orally available glycine transporter 1 inhibitor

We previously identified 3-chloro-N-{(S)-[3-(1-ethyl-1H-pyrazol-4-yl)phenyl][(2S)-piperidine-2-yl]methyl}-4-(trifluoromethyl)pyridine-2-carboxamide (5, TP0439150) as a potent and orally available glycine transporter 1 (GlyT1) inhibitor. In this article, we describe our identification of 1-methyl-N-(propan-2-yl)-N-({2-[4-(trifluoromethoxy)phenyl]pyridin-4-yl}methyl)-1H-imidazole-4-carboxamide (7n) as a structurally diverse back-up compound of 5, using central nervous system multiparameter optimization (CNS MPO) as a druglikeness guideline. Compound 7n showed a higher CNS MPO score and different physicochemical properties as compared to 5. Compound 7n exhibited potent GlyT1 inhibitory activity, a favorable pharmacokinetics profile, and elicited an increase in the cerebrospinal fluid (CSF) concentration of glycine in rats.