128988-04-5

Basic information

• Product Name: N-BIS(TERT-BUTYLPROPIONATE)AMINE
• Synonyms: N-BIS(TERT-BUTYLPROPIONATE)AMINE;Di-tert-butyl 3,3'-IMinodipropionate;3,3'-Iminodipropionic Acid Di-tert-butyl Ester;Di-tert-butyl 3,3'-Iminodipropionate
• CAS NO: 128988-04-5
• Molecular Formula: C₁₄H₂₇NO₄
• Molecular Weight: 273.37
• Mol File: 128988-04-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Refractive Index: 1.4350-1.4390
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: N-BIS(TERT-BUTYLPROPIONATE)AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BIS(TERT-BUTYLPROPIONATE)AMINE(128988-04-5)
• EPA Substance Registry System: N-BIS(TERT-BUTYLPROPIONATE)AMINE(128988-04-5)

Safety Data

• Hazardous Substances Data: 128988-04-5(Hazardous Substances Data)

Upstream product

• 1663-39-4 tert-Butyl acrylate 
• 377087-69-9 di-tert-butyl 3,3‘-(benzylazanediyl)dipropanoate 

Downstream Products

• 128988-05-6 di-tert-butyl-N-[(2-chlorophenyl)methyl]-3,3'-iminodipropionate 
• 146743-77-3 3-Allyl-4-oxo-1-trityl-piperidine-3-carboxylic acid tert-butyl ester 
• 54903-50-3 4,5,6,7-tetrahydrothieno[3,2-c]pyridine 
• 873200-25-0 C₂₄H₃₆N₂O₇ 
• 146743-76-2 3-[(2-tert-Butoxycarbonyl-ethyl)-trityl-amino]-propionic acid tert-butyl ester 

Relevant articles and documents

CONJUGATION LINKERS CONTAINING 2,3-DIAMINOSUCCINYL GROUP

Provided is a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (adual-linker) containing a 2, 3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.

CONJUGATION OF A CYTOTOXIC DRUG WITH BIS-LINKAGE

What provided is the conjugation of cytotoxic to a cell-binding molecule with a bis-linker(dual-linker) as shown in Formula (I). It provides bis-linkage methods of making a conjugate of a cytotoxic drug molecule to a cell-binding agent in a specific manner. It also relates to application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease.

CONTRAST AGENTS ENDOWED WITH HIGH RELAXIVITY

The present invention relates to a novel class of paramagnetic ion-based contrast agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or more polyhdroxylated chain, that show a pharmacokinetic profile analogous to that of the commonly used T1-general extravascular agents (NSA) but are further characterized by a higher relaxivity.