129032-45-7Relevant articles and documents
Studies directed towards the total synthesis of polyether antibiotic ionomycin: Asymmetric synthesis of fragments C(24)-C(32) and C(1)-C(23)
Yadav,Yadav, Nagendra Nath,Subba Reddy
, p. 7539 - 7549 (2015/09/07)
A convergent and stereoselective approach for the synthesis of C1-C23 and C24-C32 segments of polyether antibiotic, ionomycin has been achieved. The key steps involved in this approach are the elaboration of two advanced fragments from a common precursor
An asymmetric hydrogenation route to (-)-Spongidepsin
Zhu, Ye,Loudet, Aurore,Burgess, Kevin
supporting information; experimental part, p. 4392 - 4395 (2010/12/18)
Figure Presented. (-)-Spongidepsin 1, a cytotoxic marine natural product, was prepared via two iridium-catalyzed hydrogenation reactions; both were highly stereoselective, giving convenient access to pivotal intermediates. This synthesis was modified to g
Formal total synthesis of (-)-spongidepsin
Chandrasekhar,Yaragorla,Sreelakshmi,Reddy, Ch. Raji
, p. 5174 - 5183 (2008/12/20)
The formal total synthesis of (-)-spongidepsin is described. Three fragments I, II, and III were first prepared from readily available starting materials and then assembled to the target compound. The key steps involved in the synthesis are asymmetric α-hydroxylation, Ender's alkylation, and ring-closing metathesis reactions. An alternative route for the fragment II is also achieved involving Sharpless asymmetric epoxidation and Gilman's alkylation as key reactions.