1292280-14-8

Basic information

• Product Name: C₂₄⁽¹¹⁾CH₂₀N₄O
• Synonyms: C₂₄⁽¹¹⁾CH₂₀N₄O
• CAS NO: 1292280-14-8
• Molecular Weight: 391.449
• Mol File: 1292280-14-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄⁽¹¹⁾CH₂₀N₄O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄⁽¹¹⁾CH₂₀N₄O(1292280-14-8)
• EPA Substance Registry System: C₂₄⁽¹¹⁾CH₂₀N₄O(1292280-14-8)

Safety Data

• Hazardous Substances Data: 1292280-14-8(Hazardous Substances Data)

Upstream product

• 871507-11-8 2-((4-(4-(pyridin-4-yl)-1H-pyrazol-5-yl)phenoxy)methyl)quinoline 
• 54245-42-0 [11C]methyl iodide 

Relevant articles and documents

Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain

2-((4-(1-[11C]Methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy) methyl)-quinoline (MP-10), a specific PDE10A inhibitor (IC50 = 0.18 nM with 100-fold selectivity over other PDEs), was radiosynthesized by alkylation of the desmethyl precursor with [11C]CH3I, ～45% yield, >92% radiochemical purity, >370 GBq/μmol specific activity at end of bombardment (EOB). Evaluation in Sprague-Dawley rats revealed that [11C]MP-10 had highest brain accumulation in the PDE10A enriched-striatum, the 30 min striatum: cerebellum ratio reached 6.55. MicroPET studies of [11C]MP-10 in monkeys displayed selective uptake in striatum. However, a radiolabeled metabolite capable of penetrating the blood-brain-barrier may limit the clinical utility of [11C]MP-10 as a PDE10A PET tracer.