1292798-84-5

Basic information

• Product Name: (R)-N-[1-(1H-indol-3-yl)propan-2-yl]-2-methoxyacetamide
• CAS NO: 1292798-84-5
• Molecular Weight: 246.309
• Mol File: 1292798-84-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-N-[1-(1H-indol-3-yl)propan-2-yl]-2-methoxyacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-[1-(1H-indol-3-yl)propan-2-yl]-2-methoxyacetamide(1292798-84-5)
• EPA Substance Registry System: (R)-N-[1-(1H-indol-3-yl)propan-2-yl]-2-methoxyacetamide(1292798-84-5)

Safety Data

• Hazardous Substances Data: 1292798-84-5(Hazardous Substances Data)

Upstream product

• 64252-02-4 3-(β-nitro-β-methylvinyl)indole 
• 299-26-3 1-(1H-indol-3-yl)propan-2-amine 
• 3938-96-3 ethyl 2-methoxyacetate 
• 487-89-8 Indole-3-carboxaldehyde 

Relevant articles and documents

Straightforward preparation of biologically active 1-aryl- and 1-heteroarylpropan-2-amines in enantioenriched form

Because of the importance of developing stereoselective syntheses for single enantiomers, a selected panel of racemic biologically active 1-aryl- and 1-heteroarylpropan-2-amines has been prepared, followed by a study of their behavior in enzymatic kinetic resolution (KR) processes. For this purpose, lipase B from Candida antarctica (CAL-B) proved to be an ideal biocatalyst allowing the preparation of the corresponding enantioenriched (R)-amides and (S)-amines by aminolysis reactions. Likewise, dynamic kinetic resolutions (DKR) have been successfully achieved combining the use of CAL-B and Shvo's catalyst. This research constitutes the first example of a lipase-catalyzed DKR process of β-substituted isopropylamines.