1293288-20-6

Basic information

• Product Name: 5,7-bis(N-tert-butylcarboxamido)-8-benzyloxyquinoline
• Synonyms: 5,7-bis(N-tert-butylcarboxamido)-8-benzyloxyquinoline
• CAS NO: 1293288-20-6
• Molecular Weight: 433.55
• Mol File: 1293288-20-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,7-bis(N-tert-butylcarboxamido)-8-benzyloxyquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-bis(N-tert-butylcarboxamido)-8-benzyloxyquinoline(1293288-20-6)
• EPA Substance Registry System: 5,7-bis(N-tert-butylcarboxamido)-8-benzyloxyquinoline(1293288-20-6)

Safety Data

• Hazardous Substances Data: 1293288-20-6(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 1293288-23-9 8-(benzyloxy)-5,7-diiodoquinoline 
• 75-64-9 tert-butylamine 

Relevant articles and documents

Palladium-catalysed reactions of 8-hydroxy- and 8-benzyloxy-5,7- diiodoquinoline under aminocarbonylation conditions

Various 5-carboxamido-7-iodo-8-benzyloxyquinolines were synthesised via selective aminocarbonylation of 5,7-diiodo-8-benzyloxyquinoline in the presence of 'in situ' generated palladium(0) catalysts. Under similar conditions (50 °C, 80 bar CO), 5,7-bis(N-tert-butyl-glyoxylamido)-8-hydroxyquinoline was obtained using tert-butylamine as N-nucleophile. The unprotected 5,7-diiodo-8-hydroxyquinoline underwent dehydroiodination resulting in 8-hydroxyquinoline as the major product.