129397-33-7Relevant articles and documents
Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
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, (2008/06/13)
The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) STR1 with β-lac
Enantioselective synthesis of the (syn,anti)-1-amino-2,3-diol subunit of renin inhibition by reaction of β-lactams with a Grignard reagent
Spero,Kapadia,Farina
, p. 4543 - 4546 (2007/10/02)
A new approach to the BOC-protected amino diol 1a via the opening of 3,4-cis-disubstituted β-lactam 3 with isobutylmagnesium chloride is described. Nonracemic β-lactam 3 could be obtained by enzymatic resolution of the 3-acetoxy-β-lactam 4 or from a chira
A Stereoselective Synthesis of the (2R,3S)- and (2S,3R)-3-Amino-2-hydroxybutyric Acid Derivatives, the Key Components of a Renin Inhibitor and Bestatin
Kobayashi, Yuko,Takemoto, Yoshiji,Kamijo, Tetsuhide,Harada, Hiromu,Ito, Yoshio,Terashima, Shiro
, p. 1853 - 1868 (2007/10/02)
The title synthesis was achieved by featuring the -cycloaddition reaction of benzyloxyketene with a chiral imine derived from methyl (R)- or (S)-mandelate, alcoholysis of the formed 3,4-cis disubstituted β-lactam under acidic conditions, and reductiv