129425-59-8

Basic information

• Product Name: 3-tert-butyldimethylsilyloxy-4-(naphth-2-ylmethoxy)phenyl 2-thiazolyl ketone
• CAS NO: 129425-59-8
• Molecular Weight: 475.684
• Mol File: 129425-59-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-tert-butyldimethylsilyloxy-4-(naphth-2-ylmethoxy)phenyl 2-thiazolyl ketone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-tert-butyldimethylsilyloxy-4-(naphth-2-ylmethoxy)phenyl 2-thiazolyl ketone(129425-59-8)
• EPA Substance Registry System: 3-tert-butyldimethylsilyloxy-4-(naphth-2-ylmethoxy)phenyl 2-thiazolyl ketone(129425-59-8)

Safety Data

• Hazardous Substances Data: 129425-59-8(Hazardous Substances Data)

Upstream product

• 40610-14-8 2-lithiothiazole 
• 3943-89-3 Ethyl protocatechuate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 939-26-4 2-bromomethylnaphthyl bromide 

Relevant articles and documents

5-LIPOXYGENASE INHIBITORY THIAZOLES

The invention concerns a thiazole of the formula I, wherein Ar1 is optionally substituted aryl of up to 10 carbon atoms; A is a direct link to X, or is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene; X is oxy, thio, sulphinyl, sulphonyl or imino; Ar2 is optionally substituted phenylene, or a 6-membered heterocyclene moiety containing up to three nitrogen atoms; R1 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl; R2 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, substituted (1-4C)alkyl or (2-6C)alkanoyl; Q is optionally substituted thiazolyl; or a pharmaceutically-acceptable salt thereof. The invention also concerns processes for the manufacture of a thiazole of the formula I, or a pharmaceutically-acceptable salt thereof, and pharmaceutical compositions containing said thiazole