1295508-58-5Relevant articles and documents
Synthesis of cis -1,2-dihaloalkenes featuring palladium-catalyzed coupling of haloalkynes and α,β-unsaturated carbonyls
Chen, Dongxu,Cao, Yi,Yuan, Zheliang,Cai, Haiting,Zheng, Renwei,Kong, Lichun,Zhu, Gangguo
supporting information; experimental part, p. 4071 - 4074 (2011/06/26)
A highly regio- and stereoselective method for the synthesis of cis-1,2-dihaloalkenes through Pd-catalyzed coupling of haloalkynes and α,β-unsaturated carbonyls has been reported. Excellent stereoselectivities (Z/E up to >98:2) were observed in most cases. This method was subsequently applied to synthesize the functionalized conjugated enyne via the mono-Sonogashira coupling reaction of cis-1-chloro-2-iodoalkene.
