1295585-35-1Relevant articles and documents
2-Acylamino-5-chlorobenzophenones with enhanced selectivity towards malaria parasites
Heinrich, Swetlana,Altenk?mper, Mirko,Bechem, Benjamin,Perruchon, Johann,Ortmann, Regina,Dahse, Hans-Martin,Wang, Yulin,Lanzer, Michael,Schlitzer, Martin
, p. 1331 - 1342 (2011/04/24)
Previously we described a series of 5-acylaminobenzophenones with considerable antimalarial activity. Unfortunately, most compounds also displayed high cytotoxicity resulting in low selectivity towards malaria parasites. Through the replacement of the 5-acylamino moiety by simple chlorine and further modifications of the 2-acylamino residue we could obtain inhibitors with improved selectivity towards malaria parasites combined with an acceptable reduction of antimalarial activity.