129664-48-8

Basic information

• Product Name: 1-<3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-α-D-erythro-pentofuranosyl>-5-trifluoromethyluracil
• Synonyms: 1-<3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-α-D-erythro-pentofuranosyl>-5-trifluoromethyluracil
• CAS NO: 129664-48-8
• Molecular Weight: 573.309
• Mol File: 129664-48-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-<3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-α-D-erythro-pentofuranosyl>-5-trifluoromethyluracil(CAS DataBase Reference)
• NIST Chemistry Reference: 1-<3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-α-D-erythro-pentofuranosyl>-5-trifluoromethyluracil(129664-48-8)
• EPA Substance Registry System: 1-<3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-α-D-erythro-pentofuranosyl>-5-trifluoromethyluracil(129664-48-8)

Safety Data

• Hazardous Substances Data: 129664-48-8(Hazardous Substances Data)

Upstream product

• 3601-90-9 5-chloro-2-(((4-chlorobenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-chlorobenzoate 
• 7057-43-4 5-trifluoromethyl-2,4-bis(trimethylsilyloxy)pyrimidine 
• 21740-23-8 3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride 

Relevant articles and documents

Synthesis of trifluorothymidine: Green glycosylation condition using neither chloroform nor transition metals

A new green glycosylation condition useful for efficient large-scale preparation of trifluorothymidine 1 is described. The condition requires neither CHCl3 nor transition-metal catalysts for β-selectivity at the anomeric C1-position, which is advantageous for process development of active pharmaceutical ingredients such as 1. Key features of the condition include: (1) only an equimolar amount of trifluorothymine 2 is required, (2) the glycosylation is performed under high concentration, (3) the reaction is carried out at 50 °C to enhance the reaction.

THE SYNTHESIS OF 2'-DEOXY-5-TRIFLUOROMETHYLURIDINE UTILIZING A COUPLING REACTION

The coupling reaction between 1-α-chloro-2-deoxyribose derivative and silylated 5-trifluoromethyluracil was examined.The best stereoselectivity was obtained when the reaction was carried out using a large amount of silylated base in the presence of anhydrous zinc chloride.