1296665-06-9

Basic information

• Product Name: ethyl 5-[2-(benzyloxy)ethyl]-4-methyl-6-oxo-6H-1,3-oxazine-2-carboxylate
• Synonyms: ethyl 5-[2-(benzyloxy)ethyl]-4-methyl-6-oxo-6H-1,3-oxazine-2-carboxylate
• CAS NO: 1296665-06-9
• Molecular Weight: 317.342
• Mol File: 1296665-06-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 5-[2-(benzyloxy)ethyl]-4-methyl-6-oxo-6H-1,3-oxazine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-[2-(benzyloxy)ethyl]-4-methyl-6-oxo-6H-1,3-oxazine-2-carboxylate(1296665-06-9)
• EPA Substance Registry System: ethyl 5-[2-(benzyloxy)ethyl]-4-methyl-6-oxo-6H-1,3-oxazine-2-carboxylate(1296665-06-9)

Safety Data

• Hazardous Substances Data: 1296665-06-9(Hazardous Substances Data)

Upstream product

• 1296664-99-7 tert-butyl 2-(2-benzyloxyethyl)-3-oxobutanoate 
• 1462-37-9 bromoethyl-2-benzyl ether 
• 1296665-03-6 (Z)-tert-butyl 2-(2-benzyloxyethyl)-3-(2-ethoxy-2-oxoacetamido)-2-butenoate 

Downstream Products

• 1296665-15-0 ethyl 5-(2-(benzyloxy)ethyl)-3-(3-(tert-butoxycarbonyl)propyl)-6-methyl-3H-pyrimidin-4-one-2-carboxylate 

Relevant articles and documents

A new diversity oriented and metal-free approach to highly functionalized 3H-pyrimidin-4-ones

A new synthesis of 3H-pyrimidin-4-ones, characterized by four different sets of decorations, is presented. The strategy is based on the synthetic elaboration of readily available α-substituted β-ketoesters that, upon transformation into the corresponding acyl enamines, have been cyclized to give 6H-1,3-oxazin-6-ones. These reactive intermediates have been in turn cleanly converted into highly functionalized pyirimidinones, by treatment with an appropriate primary amine. The whole sequence does not need the use of any metal mediator or catalyst.