1296832-75-1 Usage
Description
Pioglitazone N-β-D-Glucuronide is a metabolite of Pioglitazone, which is formed through the N-glucuronidation of the thiazolidinedione ring. This biotransformation process plays a crucial role in the metabolism and elimination of Pioglitazone from the body.
Uses
Used in Pharmaceutical Industry:
Pioglitazone N-β-D-Glucuronide is used as a metabolite in the pharmaceutical industry for understanding the metabolic pathways and pharmacokinetics of Pioglitazone. This knowledge aids in the development of more effective drug formulations and dosing regimens, ultimately improving patient outcomes.
Used in Research and Development:
In the field of research and development, Pioglitazone N-β-D-Glucuronide serves as an essential compound for studying the metabolic processes of Pioglitazone and its potential interactions with other drugs or substances. This information is vital for assessing the safety, efficacy, and potential side effects of Pioglitazone in clinical settings.
Used in Drug Metabolism Studies:
Pioglitazone N-β-D-Glucuronide is used as a reference compound in drug metabolism studies, helping researchers to identify and characterize the enzymes and transporters involved in the glucuronidation process. This information is crucial for predicting drug-drug interactions and optimizing drug therapy for patients.
Used in Quality Control and Analytical Testing:
In the quality control and analytical testing of pharmaceutical products, Pioglitazone N-β-D-Glucuronide is used as a reference standard to ensure the accuracy and reliability of analytical methods employed for the quantification of Pioglitazone and its metabolites in various matrices, such as biological fluids and pharmaceutical formulations.
Check Digit Verification of cas no
The CAS Registry Mumber 1296832-75-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,9,6,8,3 and 2 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1296832-75:
(9*1)+(8*2)+(7*9)+(6*6)+(5*8)+(4*3)+(3*2)+(2*7)+(1*5)=201
201 % 10 = 1
So 1296832-75-1 is a valid CAS Registry Number.
1296832-75-1Relevant articles and documents
Identification of novel metabolic pathways of pioglitazone in hepatocytes: N-glucuronidation of thiazolidinedione ring and sequential ring-opening pathway
Uchiyama, Minoru,Fischer, Thomas,Mueller, Juergen,Oguchi, Minoru,Yamamura, Naotoshi,Koda, Hiroko,Iwabuchi, Haruo,Izumi, Takashi
, p. 946 - 956 (2011/03/18)
The metabolism of [14C]pioglitazone was studied in vitro in incubations with freshly isolated human, rat, and monkey hepatocytes. Radioactivity detection high-performance liquid chromatography analysis of incubation extracts showed the detectio