1296885-50-1

Basic information

• Product Name: N-[5-chloro-2-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-acetamide
• CAS NO: 1296885-50-1
• Molecular Weight: 251.713
• Mol File: 1296885-50-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[5-chloro-2-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[5-chloro-2-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-acetamide(1296885-50-1)
• EPA Substance Registry System: N-[5-chloro-2-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-acetamide(1296885-50-1)

Safety Data

• Hazardous Substances Data: 1296885-50-1(Hazardous Substances Data)

Upstream product

• 26488-93-7 N-(5-chloro-2-hydroxyphenyl)acetamide 
• 95-85-2 2-hydroxy-5-chloro-aniline 
• 1296885-47-6 trifluoromethanesulfonic acid 2-acetylamino-4-chloro-phenyl ester 
• 115-19-5 2-methyl-but-3-yn-2-ol 

Relevant articles and documents

2-Substituted-2,3-dihydro-1 H -quinolin-4-ones via acid-catalyzed tandem rupe rearrangement-donnelly-farrell ring closure of 2-(3′-hydroxypropynyl) anilines

A range of 2-substituted 2,3-dihydro-1H-quinolin-4-ones have been synthesized from anilines by a two-step process involving Sonogashira coupling with a propargyl alcohol then acid-catalyzed cyclization of the resulting 2-(3′-hydroxypropynyl)anilines. The cyclization reaction appears to proceed via regioselective rearrangement of the propargyl alcohol to an α,β-unsaturated ketone (Rupe rearrangement) and then 6-endo-trig ring closure (Donnelly-Farrell cyclization). The isolation of the α,β-unsaturated ketone intermediate in one example supports this pathway. Georg Thieme Verlag Stuttgart.