129714-97-2

Basic information

• Product Name: 3,5-Difluorobenzoyl chloride
• Synonyms: Benzoyl chloride, 3,5-difluoro- (9CI);3,5-Difluorobenzoyl chloride 98%;3,5-Difluorobenzoylchloride98%;3,5-Difluorobenzoyl chloride, 98% 5GR;3,5-DIFLUOROBENZOYL CHLORIDE
• CAS NO: 129714-97-2
• Molecular Formula: C₇H₃ClF₂O
• Molecular Weight: 176.55
• EINECS: 259-405-8
• Product Categories: ACIDHALIDE;Miscellaneous;Acid Halides;Carbonyl Compounds;Organic Building Blocks;Fluorine series
• Mol File: 129714-97-2.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 173-175°C
• Flash Point: 157 °F
• Appearance: /
• Density: 1.5
• Vapor Pressure: 0.67mmHg at 25°C
• Refractive Index: n20/D 1.5031(lit.)
• Water Solubility: It reacts with water.
• Sensitive: Moisture Sensitive
• BRN: 4307685
• CAS DataBase Reference: 3,5-Difluorobenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Difluorobenzoyl chloride(129714-97-2)
• EPA Substance Registry System: 3,5-Difluorobenzoyl chloride(129714-97-2)

Safety Data

• Hazard Codes: C
• Statements: 34-36/37
• Safety Statements: 23-26-27-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 129714-97-2(Hazardous Substances Data)

Usage

Description

3,5-Difluorobenzoyl chloride is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals, organic compounds, and chemical products. It is characterized by its clear light yellow liquid appearance and plays a significant role in the development of new molecules with potential applications in different industries.

Uses

Used in Pharmaceutical Industry:
3,5-Difluorobenzoyl chloride is used as a pharmaceutical intermediate for the synthesis of various drugs and medications. Its unique chemical structure allows for the creation of new molecules with potential therapeutic properties, contributing to the development of novel treatments for various medical conditions.
Used in Organic Chemistry:
In the field of organic chemistry, 3,5-Difluorobenzoyl chloride is utilized as an organic intermediate. It is involved in the formation of complex organic molecules, which can be further modified or functionalized to achieve desired properties or reactivity. This makes it a valuable component in the synthesis of a wide range of organic compounds.
Used in Chemical Synthesis:
3,5-Difluorobenzoyl chloride is also employed in chemical synthesis, where it serves as a key building block for the creation of various chemical products. Its versatility in reacting with other molecules and its unique properties make it an essential component in the development of new chemicals with specific applications in different industries, such as agriculture, materials science, and environmental science.

InChI:InChI=1/C7H3ClF2O/c8-7(11)4-1-5(9)3-6(10)2-4/h1-3H

Upstream product

• 2265-91-0 1,3-difluoro-5-iodobenzene 
• 455-40-3 3,5-difluorobenzoic acid 

Downstream Products

• 137668-47-4 (+/-)-6-methyl-6-azabicyclo<3.2.1>octan-3β-ol 3,5-difluorobenzoate 
• 851053-31-1 N-(3,5-difluorobenzoyl)pyrrolidine 
• 329946-61-4 (3,5-difluorophenyl)(3-hydroxy-2-thienyl)methanone 
• 1026001-25-1 N-(3,5-dimethoxy-2-methoxyacetyl-phenyl)-3,5-difluoro-benzamide 
• 1629888-40-9 3,5-difluoro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide 
• 1190333-57-3 2-(di-tert-butoxycarbonylamino)-5-[4-(3,5-difluorobenzoylamino)phenyl]imidazole-1-carboxylic acid tert-butyl ester 
• 1156542-50-5 chloromethyl 3,5-difluorobenzoate 
• 1061567-56-3 C₂₀H₁₈F₄N₂O₂ 
• 1015354-82-1 C₁₄H₁₁F₂NOS 
• 746612-12-4 C₁₃H₈F₃NO 
• 941099-41-8 C₁₆H₁₅F₂NO₄ 
• 1036378-10-5 C₁₅H₁₄F₂N₂O 
• 1040115-49-8 C₁₃H₆F₅NO 
• 931643-74-2 C₁₃H₇F₄NO 

Relevant articles and documents

Remarkably Efficient Iridium Catalysts for Directed C(sp2)-H and C(sp3)-H Borylation of Diverse Classes of Substrates

Here we describe the discovery of a new class of C-H borylation catalysts and their use for regioselective C-H borylation of aromatic, heteroaromatic, and aliphatic systems. The new catalysts have Ir-C(thienyl) or Ir-C(furyl) anionic ligands instead of the diamine-type neutral chelating ligands used in the standard C-H borylation conditions. It is reported that the employment of these newly discovered catalysts show excellent reactivity and ortho-selectivity for diverse classes of aromatic substrates with high isolated yields. Moreover, the catalysts proved to be efficient for a wide number of aliphatic substrates for selective C(sp3)-H bond borylations. Heterocyclic molecules are selectively borylated using the inherently elevated reactivity of the C-H bonds. A number of late-stage C-H functionalization have been described using the same catalysts. Furthermore, we show that one of the catalysts could be used even in open air for the C(sp2)-H and C(sp3)-H borylations enabling the method more general. Preliminary mechanistic studies suggest that the active catalytic intermediate is the Ir(bis)boryl complex, and the attached ligand acts as bidentate ligand. Collectively, this study underlines the discovery of new class of C-H borylation catalysts that should find wide application in the context of C-H functionalization chemistry.

Copper-mediated C–H thiolation of (hetero)arenes using weakly coordinating directing group

We have developed a copper-mediated C–H thiolation of (hetero)arenes by using monodentate amide as weakly coordinating directing group. This protocol features excellent functional group tolerance and shows satisfactory compatibility with various heterocycles, such as indole, pyrrole, imidazole, pyridine, thiophene and quinoline. The robust nature of this protocol renders that it has potential value in the synthetic application.

N-(Substituted sulfonyl)benzamide derivative and preparation method and pharmaceutical application thereof

The invention relates to an N-(substituted sulfonyl)benzamide derivative and preparation method and pharmaceutical application thereof, in particular to an N-(substituted sulfonyl)benzamide derivativeshown as general formula (I), preparation method thereof, medicinal salts of the derivative, and their application as therapeutics, especially as Nav1.7 inhibitors, wherein substituents in the general formula (I) shown in the description are defined the same as in the description.