1297302-82-9

Basic information

• Product Name: 9-O-(3,4-diflourobenzoyl)berberrubine chloride
• Synonyms: 9-O-(3,4-diflourobenzoyl)berberrubine chloride
• CAS NO: 1297302-82-9
• Molecular Weight: 497.882
• Mol File: 1297302-82-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 9-O-(3,4-diflourobenzoyl)berberrubine chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 9-O-(3,4-diflourobenzoyl)berberrubine chloride(1297302-82-9)
• EPA Substance Registry System: 9-O-(3,4-diflourobenzoyl)berberrubine chloride(1297302-82-9)

Safety Data

• Hazardous Substances Data: 1297302-82-9(Hazardous Substances Data)

Upstream product

• 633-65-8 berberine chloride 
• 15401-69-1 berberrubine chloride 
• 76903-88-3 3,4-difluorobenzoyl chloride 

Relevant articles and documents

Synthesis of 9-substituted derivatives of berberine as anti-HIV agents

Naturally occurring protoberberine alkaloids, berberine and berberrubine along with 9-substituted derivatives of berberine were assessed for the anti-human immunodeficiency virus (HIV) activity. Berberine was found to be the most active compound with an EC50 of 0.13 μM against HIV-1 NL4.3 virus in CEM-GFP cell lines. Berberrubine and two other compounds were found to be less active than berberine, at the same time they were less toxic than berberine. Enzyme based assay suggested that the anti-HIV activity of berberine and its analogs might be due to RTase inhibitory activity and some additional mechanisms.