129746-41-4

Basic information

• Product Name: 1-(3-hydroxymethylphenyl)-1H-imidazole
• Synonyms: 1-(3-hydroxymethylphenyl)-1H-imidazole
• CAS NO: 129746-41-4
• Molecular Weight: 174.202
• Mol File: 129746-41-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(3-hydroxymethylphenyl)-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-hydroxymethylphenyl)-1H-imidazole(129746-41-4)
• EPA Substance Registry System: 1-(3-hydroxymethylphenyl)-1H-imidazole(129746-41-4)

Safety Data

• Hazardous Substances Data: 129746-41-4(Hazardous Substances Data)

Upstream product

• 288-32-4 1H-imidazole 
• 87199-15-3 [3-(hydroxymethyl)phenyl]boronic acid 
• 15852-73-0 (3-Bromophenyl)methanol 
• 57455-06-8 3-iodobenzylalcohol 
• 129746-46-9 1-(3-ethoxycarbonylphenyl)imidazole 

Downstream Products

• 129747-33-7 1-(3-chloromethyl-phenyl)-1H-imidazole 

Relevant articles and documents

Relative Lability and Chemoselective Transmetallation of NHC in Hybrid Phosphine-NHC Ligands: Access to Heterometallic Complexes

The relative lability and transmetallation aptitude of trialkylphosphine and NHC donors, integrated in semi-rigid hybrid ligands attached to [Ag4Br4] pseudo-cubanes, lies in favor of the NHC and is used to selectively access unprecedented NHC complexes with heterobimetallic cores, such as Ag-Cu (4Cy) and Ag-Ir (5tBu). These can be viewed as an arrested state before the full transmetallation of both donors, which gives the homodinuclear Cu (3Cy) and Ir (6Cy) complexes. The observed NHC transmetallation aptitude and reactivity urges caution in the common notion that views the NHC as a universal spectator.

Highly functional group tolerance in copper-catalyzed N-arylation of nitrogen-containing heterocycles under mild conditions

A copper-catalyzed process has been developed for the N-arylation reaction under very mild conditions in the absence of additional ligand. This protocol could not only tolerate an array of thermally sensitive functional groups, but also achieve high chemoselectivity.

Substituted alkylamine derivatives

The substituted alkylamine derivatives represented by formula (I) STR1 wherein R1 represents (a) substituted or unsubstituted C2-6 alkenyl group, (b) substituted or unsubstituted C3-6 cycloalkenyl group, (c) substituted or unsubstituted C2-6 alkynyl group, (d) substituted or unsubstituted aryl group, (e) substituted or unsubstituted heterocyclic group, (f) fused heterocyclic group which may be substituted, or (g) group represented by the formula Ru11 -Ar wherein R11 is a heterocyclic group and Ar is a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and which may be substituted; STR2 represents a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and may be substituted by R7, X and Y are linking groups, R2 is H or lower alkyl, R3 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl or lower cycloalkyl, R4 and R5 are independently hydrogen or halogen atoms, R6 represents (a) substituted or unsubstituted acyclic hydrocarbon group which may be unsaturated, (b) substituted or unsubstituted cycloalkyl group, or (c) substituted or unsubstituted phenyl group, or non-toxic salts thereof. (E)-N-(6-6-dimethyl-2-hepten-4-ynyl)-N-ethyl-3-[4-(3-thienyl)-2-thienyl-methyloxy]benzylamine hydrochloride is a representative example. The substituted alkylamine derivatives are useful as pharmaceuticals, particularly for the treatment and prevention of hypercholesterolemia, hyperlipemia and arteriosclerosis.