1298116-72-9

Basic information

• Product Name: 1-((9H-fluoren-9-yl)methyl) 2-benzyl (S)-pyrrolidine-1,2-dicarboxylate
• Synonyms: 1-((9H-fluoren-9-yl)methyl) 2-benzyl (S)-pyrrolidine-1,2-dicarboxylate
• CAS NO: 1298116-72-9
• Molecular Weight: 427.5
• Mol File: 1298116-72-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-((9H-fluoren-9-yl)methyl) 2-benzyl (S)-pyrrolidine-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((9H-fluoren-9-yl)methyl) 2-benzyl (S)-pyrrolidine-1,2-dicarboxylate(1298116-72-9)
• EPA Substance Registry System: 1-((9H-fluoren-9-yl)methyl) 2-benzyl (S)-pyrrolidine-1,2-dicarboxylate(1298116-72-9)

Safety Data

• Hazardous Substances Data: 1298116-72-9(Hazardous Substances Data)

Upstream product

• 2446-83-5 di-isopropyl azodicarboxylate 
• 178181-74-3 benzyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-hydroxypentanoate 

Downstream Products

• 71989-31-6 Fmoc-Pro-OH 

Relevant articles and documents

Synthetic Approach to Argpyrimidine as a Tool for Investigating Nonenzymatic Posttranslational Modification of Proteins

Nonenzymatic posttranslational modifications (nPTMs) of proteins are involved in age-related, metabolic and other diseases and need to be investigated at the molecular level. Here, we describe how we used organic synthesis to enable the study of the effect of argpyrimidine (Apy), an nPTM that forms at arginine residues, on one of its target proteins. We developed an efficient approach to Apy as a universal building block for Fmoc-based solid-phase peptide synthesis that allows for the construction of peptides containing this nPTM in predetermined positions. Moreover, a straightforward one-step synthesis of protecting-group-free Apy was achieved, which enabled the preparation of gram-quantities of this noncanonical amino acid that can serve as a biomarker or a feedstock in construction of Apy-containing proteins via the expanded genetic code methods.