129979-57-3 Usage
Description
Argipressin Acetate is a peptide hormone that exhibits vasoconstrictive and antidiuretic properties. It binds to the vascular arginine vasopressin receptor, V1, with Kd values of 1.31 and 1.44 nM in A7r5 rat aortic smooth muscle cells and neonatal rat cardiomyocytes, respectively. Argipressin Acetate also stimulates the intracellular release of calcium in A7r5 cells (EC50 = 5 nM). In rat models, it has been shown to induce hypertension and tachycardia when injected into the lateral septal nuclei at a dose of 100-400 ng and increase heart rate and mean arterial pressure (MAP) when injected into the medial amygdaloid body at a dose of 150-600 ng.
Uses
Used in Pharmaceutical Industry:
Argipressin Acetate is used as a vasoconstrictor and antidiuretic agent for the treatment of conditions such as diabetes insipidus, nocturnal enuresis, and heart failure. Its ability to bind to the vascular arginine vasopressin receptor, V1, and stimulate the intracellular release of calcium makes it a valuable drug for managing these conditions.
Used in Cardiovascular Research:
Argipressin Acetate is used as a research tool in cardiovascular studies to investigate the effects of vasoconstriction and antidiuresis on heart rate, mean arterial pressure, and other related parameters. Its ability to induce hypertension and tachycardia in rat models makes it a useful compound for understanding the underlying mechanisms of these physiological responses.
Used in Smooth Muscle Cell Research:
Argipressin Acetate is used as a research tool in smooth muscle cell studies to explore the binding affinity and signaling pathways of the vascular arginine vasopressin receptor, V1. Its interaction with A7r5 rat aortic smooth muscle cells and neonatal rat cardiomyocytes provides valuable insights into the role of this receptor in smooth muscle cell function and its potential as a therapeutic target.
Check Digit Verification of cas no
The CAS Registry Mumber 129979-57-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,9,7 and 9 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 129979-57:
(8*1)+(7*2)+(6*9)+(5*9)+(4*7)+(3*9)+(2*5)+(1*7)=193
193 % 10 = 3
So 129979-57-3 is a valid CAS Registry Number.
InChI:InChI=1/C46H65N15O12S2.C2H4O2/c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25;1-2(3)4/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53);1H3,(H,3,4)/t27-,28-,29-,30-,31-,32-,33-,34-;/m0./s1
129979-57-3Relevant articles and documents
NEW SYTHESIS OF VASOPRESSIN AND ITS DE-9-GLYCINE ANALOGS
Panseuvich, O. S.,Chipens, G. I.,Korps, A. O.,Pavar, A. P.
, p. 370 - 375 (2007/10/02)
A unified scheme is proposed for the synthesis of vasopressin (I), de-9-glycinevasopressin (II), and de-9-glycinamidevasopressin (III) which has been developed on the basis of the tetrapeptide Glm-Asn-Cys(Bzl)-Pro and other homologous fragments of neurohypophyseal hormones as common initial and intermediate compounds.The free dithiols obtained by the reduction of protected derivatives of (I)-(III) by sodium in liquid ammonia have been oxidized to the corresponding cyclic disulfides (I)-(III) with the aid of 1 M H2O2 at 0-5 deg C and pH (8.5.The vasopressor activities of (I)-(III) a re, respectively 470 +/- 20, 1.7, and 0.5 IU/mg (rat, in vivo).
