129999-60-6

Basic information

• Product Name: N-(2-AMINOETHYL)-4-PIPERIDINOL
• Synonyms: Albb-005717;1-(2-aminoethyl)piperidin-4-ol(SALTDATA: 0.1H2O);1-(2-Aminoethyl)-4-hydroxypiperidine;N-(2-aminoethyl)-4-hydroxypiperidine
• CAS NO: 129999-60-6
• Molecular Formula: C₇H₁₆N₂O
• Molecular Weight: 144.214740
• Mol File: 129999-60-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 273.1 °C at 760 mmHg
• Flash Point: 119 °C
• Appearance: /
• Density: 1.062 g/cm³
• Vapor Pressure: 0.00075mmHg at 25°C
• Refractive Index: 1.517
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: N-(2-AMINOETHYL)-4-PIPERIDINOL(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-AMINOETHYL)-4-PIPERIDINOL(129999-60-6)
• EPA Substance Registry System: N-(2-AMINOETHYL)-4-PIPERIDINOL(129999-60-6)

Safety Data

• Hazardous Substances Data: 129999-60-6(Hazardous Substances Data)

Usage

General Description

N-(2-aminoethyl)-4-piperidinol, also known as N-AEP, is a chemical compound with a molecular formula C8H18N2O. It is a derivative of piperidine and contains both amine and alcohol functional groups. N-AEP is used as a synthetic intermediate in the production of pharmaceuticals and organic compounds. It is also used as a chelating agent and as a component in corrosion inhibitors. N-AEP has been studied for its potential as an anti-inflammatory and analgesic agent, and it has shown promise in preclinical models for these applications. Additionally, it has been investigated for its potential use in the treatment of alcohol and drug addiction.

InChI:InChI=1/C7H16N2O/c8-3-6-9-4-1-7(10)2-5-9/h7,10H,1-6,8H2

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 78503-67-0 4-hydroxypiperidin-1-ylacetonitrile 

Downstream Products

• 948896-01-3 N-[2-(4-hydroxypiperidin-1-yl)ethyl]benzenesulfonamide 
• 948896-05-7 N-[2-(4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)ethyl]benzenesulfonamide 
• 948895-19-0 2,6-dichloro-N-[2-(4-oxopiperidin-1-yl)ethyl]benzamide 
• 948896-03-5 N-[2-(4-oxopiperidin-1-yl)ethyl]benzenesulfonamide 
• 1415397-43-1 C₂₂H₃₁N₅O₃S 
• 1226861-07-9 N-[2-(4-Hydroxypiperidin-1-yl)ethyl]-5-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]pyridine-2-carboxamide 
• 1226860-98-5 1-[2-({6-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]pyridin-3-yl}amino)ethyl]piperidin-4-ol 
• 948895-18-9 2,6-dichloro-N-[2-(4-hydroxypiperidin-1-yl)ethyl]benzamide 
• 857637-31-1 2-(4-chloropiperidin-1-yl)ethanamine 

Relevant articles and documents

PKM2 MODULATORS AND METHODS FOR THEIR USE

Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein

ANTHARQUINONE COMPOUNDS AS ANTI CANCER COMPOUNDS

Anthraquinone compounds of the general formula (I) or a salt thereof (Formula I) in which R1 to R4 are each selected from the group consisting of H, C1-4 alkyl, X1, -NHR0N (R5)2 in which R0 is a C1-12 alkanediyl and each R5 is H or optionally substituted C1-4 alkyl, and a group of formula (II) in which at least one of R6,R7 and R8 is selected from X2 , and X2 substituted C1-4 alkyl and any others are H or C1-4 alkyl; R9 is selected from H, C1-4 alkyl, X2 and X2 substituted C1-4 alkyl; m is 0 or 1; n is 1 or 2; X1 is a halogen atom, a hydroxyl group, a C1-6 alkoxyl group, an aryloxy group or an acyloxy group; and X2 is a halogen atom, a hydroxyl group, a C1-6 alkoxyl group, an aryloxy group or an acyloxy group; provided that at least one of R1 to R4 is a group of formula (II). The N-oxides are useful prodrugs which are selectively bioreduced in hypoxic tumours to the corresponding cyclic amine derivatives. The amine compounds are cytotoxic and may be used as alkylating agents having topoisomerase II inhibiting activities in cancer therapy.