130-84-7 Usage
Description
DIMETHYL (Z)-2,3-DIACETYLOXYBUT-2-ENEDIOATE is an organic compound that plays a significant role in the synthesis of various pharmaceutical compounds. It is characterized by its unique chemical structure, which contributes to its reactivity and utility in chemical reactions.
Uses
Used in Pharmaceutical Industry:
DIMETHYL (Z)-2,3-DIACETYLOXYBUT-2-ENEDIOATE is used as a key intermediate in the synthesis of HIV-1 integrase inhibitors. These inhibitors are crucial in the development of antiretroviral drugs, which are essential for the treatment of HIV/AIDS. The compound's ability to form specific chemical bonds and its reactivity make it a valuable component in the creation of these life-saving medications.
Check Digit Verification of cas no
The CAS Registry Mumber 130-84-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 0 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 130-84:
(5*1)+(4*3)+(3*0)+(2*8)+(1*4)=37
37 % 10 = 7
So 130-84-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H12O8/c1-5(11)17-7(9(13)15-3)8(10(14)16-4)18-6(2)12/h1-4H3/b8-7-
130-84-7Relevant articles and documents
Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold
Jones, Eric D.,Vandegraaff, Nick,Le, Giang,Choi, Neil,Issa, William,MacFarlane, Katherine,Thienthong, Neeranat,Winfield, Lisa J.,Coates, Jonathan A.V.,Lu, Long,Li, Xinming,Feng, Xiao,Yu, Changjiang,Rhodes, David I.,Deadman, John J.
scheme or table, p. 5913 - 5917 (2010/11/18)
HIV integrase inhibitors based on a novel bicyclic pyrimidinone core is presented. Nine variations of the core scaffold are evaluated leading to optimization of the 6:6 core giving compound 48 with an EC50 of 3 nM against wild type HIV infected T-cells.
