130129-09-8

Basic information

• Product Name: 2-Hexynoic acid, 5-hydroxy-6-(phenylmethoxy)-, methyl ester, (R)-
• CAS NO: 130129-09-8
• Molecular Formula: C14H16O4
• Molecular Weight: 248.279
• Mol File: 130129-09-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Hexynoic acid, 5-hydroxy-6-(phenylmethoxy)-, methyl ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hexynoic acid, 5-hydroxy-6-(phenylmethoxy)-, methyl ester, (R)-(130129-09-8)
• EPA Substance Registry System: 2-Hexynoic acid, 5-hydroxy-6-(phenylmethoxy)-, methyl ester, (R)-(130129-09-8)

Safety Data

• Hazardous Substances Data: 130129-09-8(Hazardous Substances Data)

Upstream product

• 144-55-8 sodium hydrogencarbonate 
• 2930-05-4 (S)-benzyl glycidyl ether 
• 922-67-8 propynoic acid methyl ester 
• 60-29-7 diethyl ether 
• 14618-80-5 (R)-benzyl glycidol 
• 72036-29-4 methyl propiolate lithium salt 

Downstream Products

• 130625-88-6 (Z)-(R)-6-Benzyloxy-5-hydroxy-3-methyl-hex-2-enoic acid methyl ester 
• 130625-99-9 Toluene-4-sulfonic acid (3R,5R)-6-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-3-methyl-hexyl ester 
• 130626-00-5 ((1R,3R)-1-Benzyloxymethyl-3,7-dimethyl-octyloxy)-tert-butyl-dimethyl-silane 
• 130625-96-6 methyl (3S,5R)-6-benzyloxy-5-t-butyldimethylsiloxy-3-methylhexanoate 
• 130625-97-7 methyl (3S,5R)-6-benzyloxy-5-hydroxy-3-methylhexanoate 
• 130625-98-8 (3R,5R)-6-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-3-methyl-hexan-1-ol 
• 130626-02-7 (2R,4R)-1,2-O-benzylidene-4,8-dimethylnonane-1,2-diol 
• 130626-04-9 Benzoic acid (1R,3R)-1-bromomethyl-3,7-dimethyl-octyl ester 
• 130625-90-0 (4S,6R)-6-Benzyloxymethyl-4-hydroxy-4-methyl-tetrahydro-pyran-2-one 
• 130129-15-6 (4S,6R)-6-Benzyloxymethyl-4-methyl-tetrahydro-pyran-2-one 
• 120996-46-5 (R)-6-Benzyloxymethyl-5,6-dihydro-2-pyrone 
• 130625-92-2 (3R,5R)-6-Benzyloxy-3-methyl-hexane-1,3,5-triol 
• 541-07-1 (S)-3-Hydroxy-3-methyl-5-oxo-pentanoic acid 
• 130129-24-7 (4R,6R)-6-Benzyloxymethyl-4-methyl-4-phenyl-tetrahydro-pyran-2-one 

Relevant articles and documents

Optically active compounds and intermediates thereof, and process for manufacturing same

An optically active (S)- or (R)-pentane compound of the general formula (11): STR1 wherein R11, R12 and R13 independently represent a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms, R14 represents a hydroxy, protected hydroxy or oxo group, if R14 is an oxo group, the ring denoting benzene in the above formula (11) is benzoquinone, R15 represents a hydrogen atom, hydroxy or acyloxy group, R16 represents a hydroxy or acyloxy group, and the chiral central carbon marked with a symbol * in said formula (11) alternatively has one of an R-configuration and an S-configuration, is disclosed. Further, intermediate products of the compound of the formula (11) are also disclosed. Still further, a process for manufacturing the above compounds is disclosed. The compound of the formula (11) is easily synthesized from an easily available optically active starting material.

A CONVERGENT ENANTIOCONTROLLED ROUTE TO MEVALONOLACTONE AND VITAMIN E FROM (S)-O-BENZYLGLYCIDOL

A convergent enantiocontrolled route to (+) and (-)-mevalonolactones and vitamin E has been developed using (S)-O-benzylglycidol as the sole chiral block.