1301726-20-4

Basic information

• Product Name: 1-(2'-hydroxyethoxymethyl)-5-(benzylamino)uracil
• CAS NO: 1301726-20-4
• Molecular Weight: 291.307
• Mol File: 1301726-20-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2'-hydroxyethoxymethyl)-5-(benzylamino)uracil(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2'-hydroxyethoxymethyl)-5-(benzylamino)uracil(1301726-20-4)
• EPA Substance Registry System: 1-(2'-hydroxyethoxymethyl)-5-(benzylamino)uracil(1301726-20-4)

Safety Data

• Hazardous Substances Data: 1301726-20-4(Hazardous Substances Data)

Upstream product

• 78692-73-6 1-<(2-acetoxyethoxy)methyl>-5-bromouracil 
• 100-46-9 benzylamine 

Relevant articles and documents

Novel 5-(N -alkylaminouracil) acyclic nucleosides

Protocols for the two-step syntheses of new 5-(N-hydroxyalkyl- and 5-N-benzylamino)uracil acyclic nucleosides bearing various functional groups (alkoxy/hydroxy and cyano/ester) are presented. Two groups of the title compounds were synthesised via aminolysis of 5-bromouracil and, subsequently, either coupling with an alkylating agent (2-chloromethoxyethyl acetate), or Michael-type addition to acrylonitrile/methyl acrylate. The reverse sequences for both syntheses were also studied. The target molecules were designed as non-nucleoside reverse transcriptase inhibitors (NNRTI) and are analogues of 1-(hydroxyethoxymethyl)-6-thiophenylthymine (HEPT) and 3-benzyl-1- cyanomethyluracils. The obtained compounds will be used in screening tests for anti-HIV-1 activity. Georg Thieme Verlag Stuttgart New York.