130197-82-9

Basic information

• Product Name: 4-O-(2,4,6-Trimethylphenyl)-2'-deoxyuridine
• Synonyms: 4-O-(2,4,6-Trimethylphenyl)-2'-deoxyuridine
• CAS NO: 130197-82-9
• Molecular Weight: 346.383
• Mol File: 130197-82-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-O-(2,4,6-Trimethylphenyl)-2'-deoxyuridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-O-(2,4,6-Trimethylphenyl)-2'-deoxyuridine(130197-82-9)
• EPA Substance Registry System: 4-O-(2,4,6-Trimethylphenyl)-2'-deoxyuridine(130197-82-9)

Safety Data

• Hazardous Substances Data: 130197-82-9(Hazardous Substances Data)

Upstream product

• 130197-81-8 3',5'-Diacetyl-4-O-(2,4,6-triisopropylphenyl)-2'-deoxyuridine 
• 527-60-6 Mesitol 
• 119680-08-9 3',5'-Di-O-acetyl-4-O-<(2,4,6-triisopropylphenyl)sulfonyl>-2'-deoxyuridine 

Downstream Products

• 130197-84-1 3'-O-(2-Cyanoethyl-N,N'-diisopropylphosphoramido)-5'-O-(4,4'-dimethoxytrityl)-4-O-(2,4,6-trimethylphenyl)-2'-deoxyuridine 
• 951-78-0 2'-deoxyuridine 
• 951-77-9 2'-Deoxycytidine 
• 130197-83-0 5'-(4,4'-Dimethoxytrityl)-4-O-(2,4,6-trimethylphenyl)-2'-deoxyuridine 

Relevant articles and documents

Engineering Tethered DNA Molecules by the Convertible Nucleoside Approach

Non-natural functional groups, tethered to DNA, provide a chemical handle for the site-specific attachment of reporter and effector elements.Herein we report a general strategy for the synthesis of oligodeoxynucleotides bearing tethered functionality (functionally tethered oligonucleotides, FTOs).In this approach, the convertible nucleoside 4-O-(2,4,6-trimethylphenyl)-2'-deoxyuridine (TMP-dU) is introduced site-specifically into DNA during automated synthesis.Upon treatment with aqueous amines, the TMP-dU moiety undergoes nucleophilic substitution to yield an N4-alkyl-dC nucleoside - the DNA product is a dC-tethered FTO.Since the tether structure is solely determined by choice of amine used in the deprotection/conversion reaction, this convertible nucleoside approach permits a wide variety of FTOs to be synthesized from a single precursor.