13023-73-9 Usage
Description
2-(3,4-dihydroxyphenyl)-2-hydroxy-acetaldehyde, also known as Dopegal, is an aldehyde consisting of phenylacetaldehyde with three hydroxy substituents located at the alpha-, 3-, and 4-positions. It is the monoamine oxidase metabolite of dopamine, which can be toxic in concentrated amounts and may be a target for Alzheimer's or Parkinson's therapy.
Uses
Used in Pharmaceutical Industry:
2-(3,4-dihydroxyphenyl)-2-hydroxy-acetaldehyde is used as a potential therapeutic agent for neurodegenerative diseases such as Alzheimer's and Parkinson's. Its toxic nature in concentrated amounts makes it a promising target for therapy, as modulation of its levels or activity could potentially alleviate symptoms or slow disease progression.
Used in Research Applications:
2-(3,4-dihydroxyphenyl)-2-hydroxy-acetaldehyde is used as a research tool to study the role of dopamine metabolism and its implications in neurodegenerative diseases. Understanding its mechanisms of action and interactions with other biological molecules can provide valuable insights into the development of novel therapeutic strategies for Alzheimer's and Parkinson's.
Check Digit Verification of cas no
The CAS Registry Mumber 13023-73-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,0,2 and 3 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 13023-73:
(7*1)+(6*3)+(5*0)+(4*2)+(3*3)+(2*7)+(1*3)=59
59 % 10 = 9
So 13023-73-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H
13023-73-9Relevant articles and documents
Synthetic Evidence of the Amadori-Type Alkylation of Biogenic Amines by the Neurotoxic Metabolite Dopegal
J?rgensen, Steen Ingemann,Tromp, Dorette S.,Van Maarseveen, Jan H.,Vilím, Jan,Wanner, Martin J.,Zuidinga, Ed
, (2020)
The neurotransmitter metabolite 3,4-dihydroxy-phenylglycolaldehyde (dopegal) damages neurons and the myocardium by protein cross-linking, resulting in conglomerations and cell death. We investigated this process on a synthetic scale, leading to the discovery of an Amadori-type rearrangement of dopegal in the reaction with several amino acids and neuropeptides. This alkylation also occurs with neurotransmitters, suggesting an influence of dopegal on neurochemical processes. The rearrangement occurs readily under physiological conditions.
Synthesis of a Biochemically Important Aldehyde, 3,4-Dihydroxyphenylglycolaldehyde
Li, Shu Wen,Elliot, William H.,Burke, William J.
, p. 337 - 342 (1994)
3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is an important precursor of the major brain metabolites of noradrenaline, 3,4-dihydroxyphenylglycol, and 3-methoxy-4-hydroxyphenylglycol.Methods for the synthesis of DOPEGAL have been developed.The α-hydroxy an