130284-49-0

Basic information

• Product Name: 1-(2,6-diisopropylphenyl)pyrrolidine
• Synonyms: 1-(2,6-diisopropylphenyl)pyrrolidine
• CAS NO: 130284-49-0
• Molecular Weight: 231.381
• Mol File: 130284-49-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-(2,6-diisopropylphenyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,6-diisopropylphenyl)pyrrolidine(130284-49-0)
• EPA Substance Registry System: 1-(2,6-diisopropylphenyl)pyrrolidine(130284-49-0)

Safety Data

• Hazardous Substances Data: 130284-49-0(Hazardous Substances Data)

Upstream product

• 109-99-9 tetrahydrofuran 
• 24544-04-5 2,6-diisopropylbenzenamine 
• 110-52-1 1,4-dibromo-butane 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 

Relevant articles and documents

Reductive one batch synthesis of N-substituted pyrrolidines from primary amines and 2,5-dimethoxytetrahydrofuran

The construction of the pyrrolidine ring about a nitrogen of a primary amine by a reductive condensation reaction using 2,5- dimethoxytetrahydrofuran and sodium borohydride in acidic water medium is described. The reaction is fast, affords good to excellent yields and appears insensitive to electron effects and severe steric hindrance; it is found to be compatible with a large variety of aryl substituents, including nitro and oxo groups. The reaction allows the introduction of two deuterium atoms, with label conservation, in both the α-positions of the pyrrolidine ring by the use of sodium borodeuteride instead of sodium borohydride.

Phosphoryl chloride-mediated solvent-free synthesis of N-aryl-substituted azacycles from arylamines and cyclic ethers

A solvent- and metal-free protocol for preparation of N-aryl substituted azacycles from arylamines and cyclic ethers is described. In this method, the combination of POCl3 and DBU is crucial for conversion of arylamines and cyclic ethers to five- and six-membered azacycles. Without solvent, a variety of N-aryl-substituted, five-membered azacycles (pyrrolidines, 2-methylpyrrolidines, and piperidine) and six-membered azacycles (isoindolines and tetrahydroisoquinolines) are synthesized in high yields. This green method provides a sustainable and efficient approach for the preparation of azacycles from various cyclic ethers.

Dual C(sp3)?H Bond Functionalization of N-Heterocycles through Sequential Visible-Light Photocatalyzed Dehydrogenation/[2+2] Cycloaddition Reactions

Herein we describe a mild method for the dual C(sp3)?H bond functionalization of saturated nitrogen-containing heterocycles through a sequential visible-light photocatalyzed dehydrogenation/[2+2] cycloaddition procedure. As a complementary approach to the well-established use of iminium ion and α-amino radical intermediates, the elusive cyclic enamine intermediates were effectively generated by photoredox catalysis under mild conditions and efficiently captured by acetylene esters to form a wide array of bicyclic amino acid derivatives, thus enabling the simultaneous functionalization of two vicinal C(sp3)?H bonds.