130288-81-2Relevant articles and documents
A Convenient Approach to the Synthesis of Deoxyribonucleoside-3'-hydrogen Phosphonates via Bis(1,1,1,3,3,3-hexafluoro-2-propyl) Phosphonate Intermediate
Takaku, Hiroshi,Yamakage, Shunitchy,Sakatsume, Osamu,Ohtsuki, Michiya
, p. 1675 - 1678 (1988)
Transesterification of a new reagent, bis(1,1,1,3,3,3-hexafluoro-2-propyl)phosphonates was found to be very effective for the preparation of deoxyribonucleoside-3'-hydrogen phosphonates.The yields of deoxyribooligonucleotides by the H-phosphonate method o
Oxidative and nonoxidative formation of internucleotide linkages
Brill,Yau,Caruthers
, p. 6621 - 6624 (2007/10/02)
Activation of nucleoside 3'-hydrogenphosphonodithioates with iodine in the presence of nucleosides and amines yields dinucleoside phosphorodithioates and nucleoside phosphorodithioamidates, respectively. Similar activation of nucleoside 3'-methylphosphono
A CONVENIENT METHOD FOR THE SYNTHESIS OF DEOXYRIBONUCLEOSIDE 3'-HYDROGENPHOSPHONATES
Sekine, Mitsou,Narui, Sin-ichiro,Hata, Tsujiaki
, p. 1037 - 1040 (2007/10/02)
Appropriately protected 5'-O-dimethoxytrityldeoxyribonucleoside derivatives were converted to the corresponding 3'-hydrogenphosphonates by treatment with phosphinic acid in the presence of mesitylenedisulfonyl chloride via an oxidative phosphonylation process.