130332-27-3 Usage
Description
4-[[(1R)-2-[[(2R)-3-(1H-INDOL-3-YL)-2-METHYL-1-OXO-2-[[(TRICYCLO[3.3.1.13,7]DEC-2-YLOXY)CARBONYL]AMINO]PROPYL]AMINO]-1-PHENYLETHYL]AMINO]-4-OXOBUTANOIC ACID is a complex organic compound with a unique molecular structure. It is characterized by its intricate arrangement of atoms and functional groups, which may contribute to its potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
4-[[(1R)-2-[[(2R)-3-(1H-INDOL-3-YL)-2-METHYL-1-OXO-2-[[(TRICYCLO[3.3.1.13,7]DEC-2-YLOXY)CARBONYL]AMINO]PROPYL]AMINO]-1-PHENYLETHYL]AMINO]-4-OXOBUTANOIC ACID is used as a potential therapeutic agent for targeting specific receptors or biological pathways. Its unique structure may allow it to interact with cellular targets, potentially leading to the development of new treatments for various diseases.
Used in Research and Development:
In the field of research and development, 4-[[(1R)-2-[[(2R)-3-(1H-INDOL-3-YL)-2-METHYL-1-OXO-2-[[(TRICYCLO[3.3.1.13,7]DEC-2-YLOXY)CARBONYL]AMINO]PROPYL]AMINO]-1-PHENYLETHYL]AMINO]-4-OXOBUTANOIC ACID can be utilized as a starting material or a tool compound for the synthesis of novel molecules with potential biological activities. Its complex structure may provide insights into the design of new drugs or the understanding of biological processes.
Used in Chemical Synthesis:
4-[[(1R)-2-[[(2R)-3-(1H-INDOL-3-YL)-2-METHYL-1-OXO-2-[[(TRICYCLO[3.3.1.13,7]DEC-2-YLOXY)CARBONYL]AMINO]PROPYL]AMINO]-1-PHENYLETHYL]AMINO]-4-OXOBUTANOIC ACID may also find applications in chemical synthesis, where it can serve as a building block or a precursor for the creation of more complex molecules with specific properties and functions.
Biological Activity
Potent and selective CCK 2 (CCK-B) receptor antagonist that displays ~ 1600-fold selectivity over CCK 1 receptors (IC 50 values are 1.7 and 2717 nM for CCK 2 and CCK 1 respectively). Has negligible affinity at a range of other binding sites (IC 50 > 10 μ M). Exhibits anxiolytic activity following oral administration.
Check Digit Verification of cas no
The CAS Registry Mumber 130332-27-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,3,3 and 2 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 130332-27:
(8*1)+(7*3)+(6*0)+(5*3)+(4*3)+(3*2)+(2*2)+(1*7)=73
73 % 10 = 3
So 130332-27-3 is a valid CAS Registry Number.
InChI:InChI=1/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21?,22?,24?,25?,29-,32?,35+/m0/s1
130332-27-3Relevant articles and documents
Rationally Designed "Dipeptoid" Analogues of CCK. α-Methyltryptophan Derivatives as Highly Selective and Orally Active Gastrin and CCK-B Antagonists with Potent Anxiolytic Properties
Horwell, David C.,Hughes, John,Hunter, John C.,Pritchard, Martyn C.,Richardson, Reginald S.,at al.
, p. 404 - 414 (2007/10/02)
This paper describes the synthesis and structure-activity relationships (SAR) leading to the first rational design of "dipeptoid" analogues of the neuropeptide cholecystokinin (CCK).Compounds *,S*)>-4-2-3-(1H-indol-3-yl)-2-m
