1303983-13-2

Basic information

• Product Name: C₂₆H₃₁FN₄O₅
• CAS NO: 1303983-13-2
• Molecular Weight: 498.554
• Mol File: 1303983-13-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₃₁FN₄O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₃₁FN₄O₅(1303983-13-2)
• EPA Substance Registry System: C₂₆H₃₁FN₄O₅(1303983-13-2)

Safety Data

• Hazardous Substances Data: 1303983-13-2(Hazardous Substances Data)

Upstream product

• 78686-86-9 5-bromo-2-chloro-pyridine-3-carbonyl chloride 
• 1301634-69-4 C₃₄H₅₃BrClN₃O₆Si 
• 1301635-19-7 C₃₀H₃₂BrN₃O₅ 
• 404-71-7 1-fluoro-3-isocyanatobenzene 
• 627-41-8 propargyl alcohol methyl ether 
• 1301634-91-2 C₃₈H₄₀BrN₃O₆ 
• 1301634-81-0 C₂₈H₃₈BrN₃O₆ 
• 1255212-80-6 (2R,5S,6R)-tert-Butyl-2-(tert-butyldimethylsilyloxy)-4-(1-(4-methoxybenzyloxy)propan-2-ylamino)-3-methylbutyl(methyl)carbamate 

Relevant articles and documents

Synthesis of a stereochemically diverse library of medium-sized lactams and sultams via SNAr cycloetherification

We have implemented an aldol-based "build/couple/pair" (B/C/P) strategy for the synthesis of stereochemically diverse 8-membered lactam and sultam scaffolds via SNAr cycloetherification. Each scaffold contains two handles, an amine and aryl bromide, for solid-phase diversification via N-capping and Pd-mediated cross coupling. A sparse matrix design strategy that achieves the dual objective of controlling physicochemical properties and selecting diverse library members was implemented. The production of two 8000-membered libraries is discussed including a full analysis of library purity and property distribution. Library diversity was evaluated in comparison to the Molecular Library Small Molecule Repository (MLSMR) through the use of a multifusion similarity (MFS) map and principal component analysis (PCA).