130447-20-0Relevant articles and documents
Stereoconvergent negishi arylations of racemic secondary alkyl electrophiles: Differentiating between a CF3 and an alkyl group
Liang, Yufan,Fu, Gregory C.
, p. 9523 - 9526 (2015)
In this report, we establish that a readily available nickel/bis(oxazoline) catalyst accomplishes a wide array of enantioconvergent cross-couplings of arylzinc reagents with CF3-substituted racemic secondary alkyl halides, a process that necessitates that the chiral catalyst be able to effectively distinguish between a CF3 and an alkyl group in order to provide good ee. We further demonstrate that this method can be applied without modification to the catalytic asymmetric synthesis of other families of fluorinated organic compounds.
Efficient palladium-catalyzed synthesis of unsymmetrical donor-acceptor biaryls and polyaryls
Amatore, Christian,Jutand, Anny,Negri, Serge,Fauvarque, Jean-Francois
, p. 389 - 398 (2007/10/02)
4,4'-Unsymmetrically substituted biphenyls can be synthesized by cross-coupling reactions of substituted aromatic organometallic reagents and aromatic halides catalyzed by palladium complexes.This two-step method from commercially available aromatic halides has been used for the synthesis of a series of donor/acceptor para-substituted biphenyls, D-C6H4-C6H4-A, where D is an electron donor group and A an electron acceptor group, which are of interst as liquid crystal precursors and as having potential in non-linear optics.Biaryls in which the donor-phenyl moiety is replaced by a 2-furyl or 2-thienyl can be synthesized similarly.The method can also be used for the convergent synthesis of previously unreported unsymmetrically substituted polyparaphenylenes D-(C6H4)n-A (n = 3, 4).
