1304788-27-9 Usage
Description
(4S)-4,9-Bis(acetyloxy)-10-[(acetyloxy)Methyl]-4-ethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione is a complex organic compound characterized by its unique molecular structure. It is an intermediate in the synthesis of various pharmaceutical compounds, particularly those with potential applications in the medical field.
Uses
Used in Pharmaceutical Industry:
(4S)-4,9-Bis(acetyloxy)-10-[(acetyloxy)Methyl]-4-ethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione is used as an intermediate in the synthesis of Camptothecin analogs. These analogs are known for their ability to inhibit topoisomerase I, an enzyme that plays a crucial role in DNA replication. By targeting this enzyme, Camptothecin analogs can exhibit antitumor activity, making them valuable in the development of cancer treatments.
The compound's role as an intermediate in the synthesis of Camptothecin analogs highlights its importance in the pharmaceutical industry, where it contributes to the development of novel and effective cancer therapies. Its unique structure and properties make it a promising candidate for further research and development in the field of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 1304788-27-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,0,4,7,8 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1304788-27:
(9*1)+(8*3)+(7*0)+(6*4)+(5*7)+(4*8)+(3*8)+(2*2)+(1*7)=159
159 % 10 = 9
So 1304788-27-9 is a valid CAS Registry Number.
1304788-27-9Relevant articles and documents
The solvolysis of topotecan in alcohols and acetic anhydride
Li, Jiajun,Wang, Guolin,Dong, Mengjie,Zhang, Qian
scheme or table, p. 2324 - 2326 (2011/06/17)
Six derivatives of 10-hydroxycamptothecin were prepared via solvolysis of topotecan in corresponding alcohols and acetic anhydride. We attributed the specific reactivity of topotecan to the internal hydrogen-bonding between 10-hydroxy and the nitrogen atom in position 9. As a result the reaction underwent through an intermediate ortho-quionomethlide species to reach equilibrium. Bioactivity screening data showed all products could potentially inhibit the proliferation of several cancer cell lines in vitro and a bigger size group in 9-position would be favorable for the anti-tumor activities observably.
