1305287-60-8

Basic information

• Product Name: C₁₆H₁₄N₂O₃
• CAS NO: 1305287-60-8
• Molecular Weight: 282.299
• Mol File: 1305287-60-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₄N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₄N₂O₃(1305287-60-8)
• EPA Substance Registry System: C₁₆H₁₄N₂O₃(1305287-60-8)

Safety Data

• Hazardous Substances Data: 1305287-60-8(Hazardous Substances Data)

Upstream product

• 589-10-6 phenoxyethyl bromide 
• 5330-05-2 4-nitrophthalimide potassium salt 
• 1002650-14-7 C₁₆H₁₂N₂O₅ 

Downstream Products

• 1428333-13-4 C₂₃H₂₀N₂O₅S 

Relevant articles and documents

A new series of N2-substituted-5-(p-toluenesulfonylamino)phthalimide analogues as α-glucosidase inhibitors

Several members of a new family of non-sugar-type α-glycosidase inhibitors, bearing a 5-(p-toluenesulfonylamino)phthalimide moiety and various substituent at the N2 position, were synthesized and their activities were investigated. The newly synthesized compounds displayed different inhibition profile towards yeast α-glycosidase and rat intestinal α-glycosidase. Almost all the compounds had strong inhibitory activities against yeast α-glycosidase. Regarding rat intestinal α-glycosidase, only analogs with N2-aromatic substituents displayed varying degrees of inhibitory activities on rat intestinal maltase and lactase and nearly all compounds showed no inhibition against rat intestinal α-amylase. Structure-activity relationship studies indicated that 5-(p- toluenesulfonylamino)phthalimide moiety is a favorable scaffold to exert the α-glucosidase inhibitory activity and substituents at the N2 position have considerable influence on the efficacy of the inhibition activities.