130654-80-7

Basic information

• Product Name: Benzene, 1-methoxy-2-(3,3,3-trifluoro-1-propynyl)-
• CAS NO: 130654-80-7
• Molecular Formula: C10H7F3O
• Molecular Weight: 200.16
• Mol File: 130654-80-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzene, 1-methoxy-2-(3,3,3-trifluoro-1-propynyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-methoxy-2-(3,3,3-trifluoro-1-propynyl)-(130654-80-7)
• EPA Substance Registry System: Benzene, 1-methoxy-2-(3,3,3-trifluoro-1-propynyl)-(130654-80-7)

Safety Data

• Hazardous Substances Data: 130654-80-7(Hazardous Substances Data)

Upstream product

• 105273-33-4 1-chloro-2-(trimethylsilylethynyl)benzene 
• 615-41-8 2-iodochlorobenzene 
• 887144-97-0 Togni's reagent 
• 767-91-9 1-ethynyl-2-methoxybenzene 
• 529-28-2 4-iodoanisol 
• 672339-38-7 (Z)-2,3,3,3-tetrafluoro-1-iodoprop-1-ene 
• 661-54-1 3,3,3-trifluoroprop-1-yne 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 1514-82-5 2-bromo-3,3,3-trifluoropropene 
• 7342-00-9 3-(2-methoxyphenyl)prop-2-ynoic acid 
• 40230-91-9 [(2-methoxyphenyl)ethynyl]trimethylsilane 
• 77152-08-0 trifluoromethylcopper(I) 

Downstream Products

• 1567353-96-1 (Z)-3,3,3-trifluoro-1-(2-methoxyphenyl)-1-tributylstannyl-2-trimethylsilyl-1-propene 
• 1567354-02-2 (Z)-3,3,3-trifluoro-1-(2-methoxyphenyl)-2-tributylstannyl-1-trimethylsilyl-1-propene 
• 130654-92-1 o-(3,3,3-trifluoro-1-iodo-1-propenyl)anisole 
• 130654-91-0 3,3,3-trifluoro-1-(2-methoxyphenyl)propan-1-one 
• 1309369-62-7 C₁₇H₁₃F₃O₃ 

Relevant articles and documents

Regioselective Gold-Catalyzed Hydration of CF3- and SF5-alkynes

The regioselective gold-catalyzed hydration of CF3- and SF5-alkynes is described. The corresponding trifluoromethylated and pentasulfanylated ketones are obtained in up to 91% yield as single regioisomers showcasing the use of CF3 and SF5 as highly efficient directing groups in this reaction. Notably, this transformation represents the first use of CF3- and SF5-alkynes in gold catalysis.

Cu(I)/Ag(I)-mediated decarboxylative trifluoromethylation of arylpropiolic acids with Me3SiCF3at room temperature

A novel Cu(I)/Ag(I)-mediated decarboxylative trifluoromethylation of arylpropiolic acids with Me3SiCF3has been developed for the construction of Csp-CF3bond under mild conditions. This method proceeds smoothly at room temperature and shows a widely functional compatibility, providing a series of corresponding trifluoromethylated acetylenyl-containing aromatics in good yields.

Practical methods for the synthesis of trifluoromethylated alkynes: Oxidative trifluoromethylation of copper acetylides and alkynes

Two practical and complementary methods are reported for the synthesis of trifluoromethylated alkynes. The first one, a mix-and-stir process, is based on the oxidative trifluoromethylation of readily available and bench-stable copper acetylides while the second one, which displays a broad substrate scope and has several advantages over existing procedures, is based on the oxidative copper-catalyzed direct trifluoromethylation of terminal alkynes. Both reactions provide user-friendly processes for the synthesis of trifluoromethylated acetylenes which can be easily obtained from readily available starting materials.