1306651-85-3Relevant articles and documents
Synthesis of α,ω-Bis-Enones by the Double Addition of Alkenyl Grignard Reagents to Diacid Weinreb Amides
Wiesler, Stefan,Bau, Michael A.,Niepel, Thomas,Younas, Sara L.,Luu, Hieu-Trinh,Streuff, Jan
, p. 6246 - 6260 (2019/09/10)
An efficient double addition of substituted alkenylmagnesium bromides to bis-Weinreb amides has been developed, giving α,ω-bis-enones that are building blocks for certain drugs and polymers. Furthermore, reliable protocols for the preparation of the requi
Synthesis of poly β ketoesters via double acylketene trapping
Palma, Aniello,Serginson, James M.,Barrett, Anthony G.M.
, p. 674 - 676 (2015/01/30)
The synthesis and characterization of polymeric β ketoesters is herein reported. These polymers were prepared by allowing highly electrophilic acylketenes, generated in situ via thermolysis of stable 6-substituted-2,2-dimethyl-4H-1,3-dioxin-4-ones, to rea
One-pot transition-metal-free synthesis of weinreb amides directly from carboxylic acids
Niu, Teng,Wang, Ke-Hu,Huang, Danfeng,Xu, Changming,Su, Yingpeng,Hu, Yulai,Fu, Ying
, p. 320 - 330 (2014/02/14)
Weinreb amides were prepared directly from carboxylic acids, N,O-dimethylhydroxylamine, and phosphorus trichloride in one pot at 60 °C in toluene in high yields, thus avoiding the separation of the moisture and air sensitive intermediate P[NMe(OMe)]3 in advance. Sterically hindered carboxylic acids also give the corresponding Weinreb amides in excellent yields. Various functional groups are tolerated on the carboxylic acid. The method, which is a simple process and gives high yields, is suitable for large-scale production. Georg Thieme Verlag KG Stuttgart · New York.