130688-82-3Relevant articles and documents
Zeolites as Catalysts in the Fischer Indole Synthesis. Enhanced Regioselectivity for Unsymmetrical Ketone Substrates
Prochazka, Michal P.,Eklund, Lars,Carlson, Rolf
, p. 610 - 613 (2007/10/02)
The use of zeolites as catalysts in the Fischer indole synthesis has been studied on five unsymmetrical ketone substrates with 14 different zeolites.Both the corresponding phenylhydrazone and the parent ketone in the presence of phenylhydrazine were used as substrates.Zeolites which catalysed the indolization of the phenylhydrazones were also active in the direct conversion of the parent ketone.For substrates which gave mixtures of isomeric indoles under homogeneous, classical indolization conditions in acetic acid, it was found that the distribution of regioisomersof the indoles formed was altered considerably by zeolite catalysis and that the distribution was dependent on the type of zeolite used.A one-pot synthetic procedure for indole synthesis from the parent ketone and phenylhydrazine is described.