13072-69-0

Basic information

• Product Name: N-(1-ADAMANTYL)UREA
• Synonyms: 1-adamantylurea;tricyclo(3.3.1.1(sup3,7))dec-1-yl-ure;tricyclo(3.3.1.1(sup3,7))dec-1-ylurea;SALOR-INT L496030-1EA;N-(1-ADAMANTYL)UREA;N-tricyclo(3.3.1.13,7)dec-1-ylurea;N-(1-ADAMANTYL)UREA 98%;N-(1-Adamantyl)urea,98%
• CAS NO: 13072-69-0
• Molecular Formula: C₁₁H₁₈N₂O
• Molecular Weight: 194.27
• EINECS: 235-965-9
• Product Categories: Adamantane derivatives
• Mol File: 13072-69-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 250 °C
• Boiling Point: 330.73°C (rough estimate)
• Flash Point: 141°C
• Appearance: /
• Density: 1.17±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.000639mmHg at 25°C
• Refractive Index: 1.4720 (estimate)
• CAS DataBase Reference: N-(1-ADAMANTYL)UREA(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-ADAMANTYL)UREA(13072-69-0)
• EPA Substance Registry System: N-(1-ADAMANTYL)UREA(13072-69-0)

Safety Data

• Safety Statements: 24/25
• RTECS: YU4560000
• HazardClass: IRRITANT
• Hazardous Substances Data: 13072-69-0(Hazardous Substances Data)

Usage

Chemical Properties

WHITE SHINY CRYSTALS

Purification Methods

Wash the urea with H2O and dioxane and recrystallise it from EtOH. [Stetter & Wulff Chem Ber 95 2302 1962.]

InChI:InChI=1/C11H18N2O/c12-10(14)13-11-4-7-1-8(5-11)3-9(2-7)6-11/h7-9H,1-6H2,(H3,12,13,14)

Upstream product

• 665-66-7 amantadine hydrochloride 
• 57-13-6 urea 
• 768-95-6 1-adamanthanol 
• 281-23-2 adamantane 
• 32314-61-7 1-nitroxyadamantane 
• 15784-82-4 N-(adamantan-1-yl)cyanamide 
• 768-94-5 1-Adamantanamine 
• 768-90-1 1-Adamantyl bromide 

Downstream Products

• 665-66-7 amantadine hydrochloride 
• 768-94-5 1-Adamantanamine 

Relevant articles and documents

REACTIONS OF TRIFORMYLMETHANE WITH ADAMANTANE DERIVATIVES CONTAINING PRIMARY AMINO GROUP

Six new compounds were obtained by condensation of triformylmethane with some aminoadamantane derivatives.The study also includes 7-amino-1,3,5-triazaadamantane.

Method for continuous production of adamantanamine hydrochloride

The invention aims to provide a method for continuous production of adamantanamine hydrochloride by a high-temperature kneading/spiral propelling reactor. In comparison with a traditional batch reactor, the reaction equipment is small in size and has good reaction stability, helps improve production efficiency by continuous reaction production of amantadine products and more importantly helps avoid the temperature runaway problem of the system, and has good safety. The invention has the prominent characteristics as follows: by using the high-temperature kneading/spiral propelling reactor as the reaction equipment, an aminolysis material can be continuously produced, retention time of the aminolysis material in the equipment can be controlled, side effects are reduced, and the aminolysis material can be removed out of the equipment periodically; in the feeding process, dramatic temperature rise of the system is avoided; and under the condition of high reaction yield, the equipment is small in size, is safe and simple to operate, and has good industrial application value.

One-Pot Amination of Cage Hydrocarbons

A one-pot procedure has been proposed for the synthesis of amines directly from cage hydrocarbons. A number of cage amines have been synthesized by treatment of adamantane, its homologs, and structurally related cage hydrocarbons with nitric acid in acetic acid and subsequent addition of urea and heating.