130728-71-1

Basic information

• Product Name: 2-phenyl-1H-benzo[e]isoindole-1,3(2H)-dione
• Synonyms: 2-phenyl-1H-benzo[e]isoindole-1,3(2H)-dione
• CAS NO: 130728-71-1
• Molecular Weight: 273.291
• Mol File: 130728-71-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-phenyl-1H-benzo[e]isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-1H-benzo[e]isoindole-1,3(2H)-dione(130728-71-1)
• EPA Substance Registry System: 2-phenyl-1H-benzo[e]isoindole-1,3(2H)-dione(130728-71-1)

Safety Data

• Hazardous Substances Data: 130728-71-1(Hazardous Substances Data)

Upstream product

• 2088-87-1 naphthalene-1,2-dicarboxylic acid 
• 62-53-3 aniline 
• 86-55-5 1-naphthalenecarboxylic acid 
• 103-71-9 phenyl isocyanate 
• 93-09-4 naphthalene-2-carboxylate 
• 201230-82-2 carbon monoxide 
• 66-77-3 1-naphthaldehyde 

Relevant articles and documents

Carbonylation Access to Phthalimides Using Self-Sufficient Directing Group and Nucleophile

Herein we report a novel palladium-catalyzed oxidative carbonylation reaction for the synthesis of phthalimides with high atom- and step-economy. In our strategy, the imine and H2O, which are generated in situ from the condensation of aldehyde and amine, serve as self-sufficient directing group and nucleophile, respectively. This method provides rapid access to phthalimides starting from readily available materials in a one-pot manner. Various phthalimide derivatives are constructed efficiently, including medicinally and biologically active phthalimide-containing compounds.

A rhodium-catalyzed cascade cyclization: Direct synthesis of N-substituted phthalimides from isocyanates and benzoic acids

A rhodium(III)-catalyzed amidation between benzoic acids and isocyanates via direct functionalization of an ortho C-H bond followed by intramolecular cyclization is described. This cascade cyclization affords N-substituted phthalimides in one step in 26-91% yields. The reaction is highly atom-economical, since no theoretical waste except for water is generated in the reaction.