1307308-66-2

Basic information

• Product Name: ethyl 2-methoxycarbonylmethyl-1,5-dimethyl-1H-imidazole-4-carboxylate
• CAS NO: 1307308-66-2
• Molecular Weight: 240.259
• Mol File: 1307308-66-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-methoxycarbonylmethyl-1,5-dimethyl-1H-imidazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-methoxycarbonylmethyl-1,5-dimethyl-1H-imidazole-4-carboxylate(1307308-66-2)
• EPA Substance Registry System: ethyl 2-methoxycarbonylmethyl-1,5-dimethyl-1H-imidazole-4-carboxylate(1307308-66-2)

Safety Data

• Hazardous Substances Data: 1307308-66-2(Hazardous Substances Data)

Upstream product

• 5408-04-8 ethyl 2-hydroxyimino-3-oxobutanoate 
• 141-97-9 ethyl acetoacetate 
• 1100817-23-9 ethyl 1,5-dimethyl-3-oxido-1H-imidazole-4-carboxylate 

Relevant articles and documents

Straightforward access to (imidazol-2-yl)acetates by reaction of 2-unsubstituted imidazole 3-oxides with dimethyl acetylenedicarboxylate

A new method for the preparation of 1,4,5-trisubstituted (imidazol-2-yl)acetates, based on the reaction of the corresponding imidazole 3-oxides with dimethyl acetylenedicarboxylate (DMAD) is described. Formation of the products is rationalized by a formal 1,3-dipolar cycloaddition and subsequent oxaloyl cleavage. 1,4,5-Trisubstituted imidazole 3-oxides bearing an electron-withdrawing substituent at C(4), easily react with dimethyl acetylenedicarboxylate (DMAD), yielding the corresponding oxobutanoates, which subsequently, in a one-pot procedure undergo hydrolysis through an "oxaloyl cleavage" mode. New (imidazol-2-yl)acetates were isolated in high yields. Copyright