13076-17-0Relevant articles and documents
Studies on the epimerization of diastereomeric lactides
Shuklov, Ivan A.,Jiao, Haijun,Schulze, Joachim,Tietz, Wolfgang,Kühlein, Klaus,B?rner, Armin
, p. 1027 - 1030 (2011)
The epimerization of chiral lactides was studied in the presence of various homogeneous and heterogeneous bases. Some solvent/base systems were found to promote epimerization at room temperature efficiently. Side reactions such as polymerization were not observed or occurred only slowly. This new protocol offers the opportunity of the transformation of meso-lactide into rac-lactide. Therefore it can reduce the overall manufacturing costs of polylactides, a problem which currently hampers the broad application of those environmentally friendly polymers in a large scale.
TECHNOLOGICAL METHOD FOR SYNTHESIS OF OPTICALLY PURE L-/D-LACTIDE CATALYZED BY BIOGENIC GUANIDINE
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Paragraph 0040-0042, (2016/03/26)
A technological method for synthesizing optically pure L-/D-lactide by using a biogenic guanidine catalysis method. The method of the present invention comprises: by using biogenic guanidine creatinine (CR) as a catalyst and L-/D-lactic acid (90% of mass content) as a raw material, synthesizing optically pure L-/D-lactide by using a reactive reduced pressure distillation catalysis method. The method of the present invention has advantages that the used catalyst is biogenic guanidine creatinine and free of toxicity, metal, and cytotoxicity; the synthesized lactide is high in optical purity (the specific rotation of the L-lactide [α]25 D=?276??280, and the specific rotation of the D-lactide [α]25 D=280), and does not contain any metal; the amount of the catalyst used in reaction is low, the technological process is simplified (a process for rectifying and purifying a crude lactide product by using a conventional method is avoided); and the technological method is simple and convenient to operate and easy in industrial implementation.
Synthesis of (R)-lactic acid and (2R,5R)-2-tert-Butyl-5-methyl-1,3-dioxolan-4-one
Aitken, R. Alan,Meehan, Anna,Power, Lynn A.
, p. 1557 - 1559 (2015/06/02)
Abstract A convenient procedure for the synthesis of very expensive (R)-lactic acid from relatively inexpensive (R)-alanine is described. Its subsequent conversion into a chiral dioxolanone can be carried out by using an inexpensive pivalaldehyde-tert-butanol mixture.