130761-99-8

Basic information

• Product Name: 1-N-CBZ-3-PYRROLIDINONE
• Synonyms: BENZYL 3-OXOPYRROLIDINE-1-CARBOXYLATE;3-OXO-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER;3-OXO-1-PYRROLIDINECARBOXYLIC ACID, PHENYLMETHYL ESTER;1-Z-3-PYRROLIDINONE;1-CARBOBENZYLOXY-3-PYRROLIDINONE;1-CBZ-3-PYRROLIDINONE;N-CBZ-3-PYRROLIDINONE;3-Oxocyclopentanecarboxylic acid phenylmethyl ester
• CAS NO: 130761-99-8
• Molecular Formula: C₁₃H₁₄O₃
• Molecular Weight: 219.24
• Mol File: 130761-99-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 341℃
• Flash Point: >230 °F
• Appearance: /
• Density: 1.1897 g/mL at 25 °C
• Refractive Index: n20/D 1.5410
• CAS DataBase Reference: 1-N-CBZ-3-PYRROLIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-N-CBZ-3-PYRROLIDINONE(130761-99-8)
• EPA Substance Registry System: 1-N-CBZ-3-PYRROLIDINONE(130761-99-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-40
• Safety Statements: 23-24/25-36/37
• WGK Germany: 2
• Hazardous Substances Data: 130761-99-8(Hazardous Substances Data)

Usage

General Description

1-N-CBZ-3-Pyrrolidinone, also known as N-tert-butoxycarbonyl-3-pyrrolidinone, is a chemical compound commonly used in the synthesis of pharmaceuticals and agrochemicals. It is a nontoxic, white crystalline powder with a melting point of 74-77°C. 1-N-CBZ-3-PYRROLIDINONE is used as a reagent in the production of various drugs and organic compounds due to its versatile and reactive nature. It serves as a key intermediate in the manufacturing process of drugs such as racetam and oxiracetam, as well as in the production of compounds used in the agricultural industry. With its importance in the production of various pharmaceutical and agrochemical products, 1-N-CBZ-3-Pyrrolidinone plays a crucial role in the synthesis of many important compounds.

Upstream product

• 916736-76-0 benzyl 3-hydroxycyclopentanecarboxylate 
• 100-51-6 benzyl alcohol 
• 98-78-2 3-Oxo-cyclopentanecarboxylic acid 
• 100-39-0 benzyl bromide 

Downstream Products

• 1233927-24-6 3-phenylaminocyclopentanecarboxylic acid benzyl ester 
• 1309166-47-9 benzyl 1-oxaspiro[4.4]nonane-7-carboxylate 
• 1309166-45-7 benzyl 3-hydroxy-3-(3-hydroxypropyl)cyclopentanecarboxylate 
• 1309166-43-5 benzyl 3-allyl-3-hydroxycyclopentanecarboxylate 
• 128095-32-9 (±)-cis-benzyl 3-hydroxycyclopentane-1-carboxylate 
• 916736-73-7 benzyl 3,3-difluoro-1-hydroxycyclopentanecarboxylate 
• 916736-25-9 N-((1R)-1-{5-[5-chloro-3-fluoro-2-(2-methyl-2H-tetrazol-5-yl)phenyl]-3-fluoropyridin-2-yl}ethyl)-3,3-difluoro-1-hydroxycyclopentanecarboxamide 

Relevant articles and documents

3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR

The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

BENZAMIDE IMIDAZOPYRAZINE BTK INHIBITORS

Provided are Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, or their use in therapy.

Substituted pyrazolo-piperazines as casein kinase 1 δ/ε inhibitors

The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.