130780-36-8 Usage
Description
(S)-α-methyl(2-fluorophenyl)alanine is a non-proteinogenic amino acid, an enantiomer of α-methylphenylalanine, and is utilized as a building block in the synthesis of pharmaceuticals and biologically active compounds. It is significant in medicinal chemistry for its potential to modulate protein-protein interactions and mimic natural amino acids in peptide and protein structures, leading to altered functional properties. The presence of a fluorine atom in its structure provides unique properties that are beneficial in drug design and molecular imaging.
Uses
Used in Pharmaceutical Synthesis:
(S)-α-methyl(2-fluorophenyl)alanine is used as a building block for the synthesis of various pharmaceuticals and biologically active compounds, contributing to the development of new drugs with improved properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (S)-α-methyl(2-fluorophenyl)alanine is used as a modulator of protein-protein interactions, playing a crucial role in the design and development of drugs targeting specific protein interactions.
Used in Drug Discovery:
(S)-α-methyl(2-fluorophenyl)alanine is employed in drug discovery as a valuable tool for creating peptide and protein molecules with altered functional properties, enhancing the effectiveness of potential therapeutic agents.
Used in Molecular Imaging:
The unique properties of the fluorine atom in (S)-α-methyl(2-fluorophenyl)alanine make it useful in molecular imaging applications, where its incorporation into imaging agents can improve the detection and visualization of biological processes.
Used in Drug Design:
(S)-α-methyl(2-fluorophenyl)alanine is used in drug design to exploit the unique properties of the fluorine atom, which can lead to the development of more effective and targeted therapeutics.
Check Digit Verification of cas no
The CAS Registry Mumber 130780-36-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,7,8 and 0 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 130780-36:
(8*1)+(7*3)+(6*0)+(5*7)+(4*8)+(3*0)+(2*3)+(1*6)=108
108 % 10 = 8
So 130780-36-8 is a valid CAS Registry Number.
130780-36-8Relevant articles and documents
A new approach to the efficient method for the asymmetric synthesis of (S)-O-, M-, P-fluorophenylalanines and their 2-methyl-substituted analogs
Saghiyan, Ashot S.,Petrosyan, Satenik G.,Manasyan, Luiza L.,Dadayan, Slavik A.,Geolchanyan, Arpine V.,Panosyan, Henry A.,Maleev, Victor I.,Khrustalev, Victor N.
scheme or table, p. 493 - 506 (2011/04/16)
The reactions of asymmetric C-alkylation of glycine and alanine in NiII complexes of their Schiff's bases with modified chiral auxiliaries (S)-2-N-[(N0-2-chlorobenzylprolyl)- amino]benzophenone and (S)-2-N-[N′-(3, 4-dimethylbenzylprolyl)amino]benzophenone by fluorine-substituted benzyl halogenides have been studied. As a result, a highly stereoselective and relatively rapid method for the asymmetric synthesis of (S)-o-, m-, p-fluorophenylalanines and their 2-methyl substituted analogs has been developed.
ASYMMETRIC SYNTHESIS OF HETEROORGANIC ANALOGS OF NATURAL COMPOUNDS. 2. A CONVENIENT PREPARATIVE METHOD FOR THE SYNTHESIS OF ENANTIOMERICALLY PURE (S)-(-)-o-, m-, and p-FLUOROPHENYLALANINES AND THEIR 2-METHYL-SUBSTITUTED ANALOGS.
Soloshonok, V. A.,Belokon', Yu. N.,Kukhar', V. P.,Chernoglazova, N. I.,Saporovskaya, M. B.,et al.
, p. 1479 - 1485 (2007/10/02)
A convenient preparative method for the synthesis of the enantiomerically pure o-, m-, and p-fluorophenylalanines and their α-methyl-substituted analogs by means of the alkylation with the corresponding fluorine-containing benzyl chlorides of glycine and
