130791-47-8

Basic information

• Product Name: (S)-1-(4-Phenyl-butyryl)-piperidine-2-carboxylic acid
• Synonyms: (S)-1-(4-Phenyl-butyryl)-piperidine-2-carboxylic acid
• CAS NO: 130791-47-8
• Molecular Weight: 275.348
• Mol File: 130791-47-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-(4-Phenyl-butyryl)-piperidine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(4-Phenyl-butyryl)-piperidine-2-carboxylic acid(130791-47-8)
• EPA Substance Registry System: (S)-1-(4-Phenyl-butyryl)-piperidine-2-carboxylic acid(130791-47-8)

Safety Data

• Hazardous Substances Data: 130791-47-8(Hazardous Substances Data)

Upstream product

• 18496-54-3 phenylbutyric acid chloride 
• 3105-95-1 pipecolinic acid 

Relevant articles and documents

Synthesis of prolyl endopeptidase inhibitors and evaluation of their structure-activity relationships: In vitro inhibition of prolyl endopeptidase from canine brain

By chemical modification of a known prolyl endopeptidase (PEP) inhibitor (N-[N-(4-phenylbutanoyl)-L-prolyl]pyrrolidine; SUAM-1221), several arylalkanoyl derivatives (V-1-27) were synthesized and tested for in vitro inhibitory activity towards PEP from canine brain. Among them, 4-(2- thienyl)butanoyl derivatives (V-24-27) showed more potent PEP-inhibitory activity than SUAM-1221. The structure-activity relationships of these compounds are discussed.