13080-79-0Relevant articles and documents
Palladium-catalyzed cascade cyclization of allylamine-tethered alkylidenecyclopropanes: Facile access to iodine/difluoromethylene- and perfluoroalkyl-containing 1-benzazepine scaffolds
Yu, Liu-Zhu,Zhu, Zi-Zhong,Hu, Xu-Bo,Tang, Xiang-Ying,Shi, Min
supporting information, p. 6581 - 6584 (2016/06/01)
The unprecedented palladium-catalyzed cascade cyclization of allylamine-tethered alkylidenecyclopropanes with an ethyl difluoroiodoacetate or perfluoroalkylated reagent is developed, providing facile access to a variety of synthetically and medicinally valuable iodine/difluoromethylene- and perfluoroalkyl-containing 1-benzazepine frameworks. These reactions exhibited good yields and functional group tolerance via a radical mechanism.