1308310-83-9

Basic information

• Product Name: C₁₃⁽¹¹⁾CH₁₁N₃O₃
• CAS NO: 1308310-83-9
• Molecular Weight: 268.249
• Mol File: 1308310-83-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃⁽¹¹⁾CH₁₁N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃⁽¹¹⁾CH₁₁N₃O₃(1308310-83-9)
• EPA Substance Registry System: C₁₃⁽¹¹⁾CH₁₁N₃O₃(1308310-83-9)

Safety Data

• Hazardous Substances Data: 1308310-83-9(Hazardous Substances Data)

Upstream product

• 911132-05-3 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide hydrochloride 
• 63560-70-3 [¹¹C]phosgene 

Downstream Products

• 1308310-84-0 C₂₀⁽¹¹⁾CH₁₆ClF₃N₄O₃ 

Relevant articles and documents

Sorafenib: Radiosynthesis and preliminary PET study of brain uptake in P-gp/Bcrp knockout mice

Sorafenib (Nexavar, BAY43-9006, 1) is a second-generation, orally active multikinase inhibitor that is approved for the treatment of some cancers in patients. In this Letter, we developed [11C]1 as a novel positron emission tomography (PET) probe, and evaluated the influence of ABC transporters-mediated efflux on brain uptake using PET with [11C]1 in P-glycoprotein (P-gp)/breast cancer resistance protein (Bcrp) knockout mice versus wild-type mice. [11C]1 was synthesized by the reaction of hydrochloride of aniline 2 with [11C]phosgene ([11C] COCl2) to give isocyanate [11C]6, followed by reaction with another aniline 3. Small-animal PET study with [11C]1 indicated that the radioactivity level (AUC0-60 min, SUV × min) in the brains of P-gp/Bcrp knockout mice was about three times higher than in wild-type mice.