1308660-41-4Relevant articles and documents
Trifluoroethanol and liquid-assisted grinding method: a green catalytic access for multicomponent synthesis
Lohar, Trushant,Mane, Ananda,Kamat, Siddharth,Kumbhar, Arjun,Salunkhe, Rajashri
, p. 1919 - 1933 (2018)
An efficient and versatile mechanochemical route for the synthesis of chromene and isoindolo[2,1-a]quinazoline scaffolds has been developed via a simple mortar and pestle liquid-assisted grinding method using 2,2,2-trifluoroethanol (TFE) as an efficient catalyst. The present protocol is very efficient as it offers reaction in mild reaction condition, cleaner reaction profiles, effortless work-up step with excellent purity, and high yield of the desired products with short reaction time.
A new three-component reaction: Green synthesis of novel isoindolo[2,1-a]quinazoline derivatives as potent inhibitors of TNF-α
Kumar, K. Siva,Kumar, P. Mahesh,Kumar, K. Anil,Sreenivasulu,Jafar, Ahamed A.,Rambabu,Krishna, G. Rama,Reddy, C. Malla,Kapavarapu, Ravikumar,Shivakumar,Priya, K. Krishna,Parsa, Kishore V. L.,Pal, Manojit
supporting information; experimental part, p. 5010 - 5012 (2011/06/09)
Concurrent construction of five and six membered fused N-heretocyclic ring was achieved via a conceptually new three-component reaction affording 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-diones as novel inhibitors of TNF-α in vitro. This represents one of the few examples of direct TNF-α inhibition by small molecules.
