130872-52-5

Basic information

• Product Name: Benzoic acid, 4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, ethyl ester
• CAS NO: 130872-52-5
• Molecular Formula: C17H13NO4
• Molecular Weight: 295.295
• Mol File: 130872-52-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, ethyl ester(130872-52-5)
• EPA Substance Registry System: Benzoic acid, 4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, ethyl ester(130872-52-5)

Safety Data

• Hazardous Substances Data: 130872-52-5(Hazardous Substances Data)

Upstream product

• 88-95-9 Phthaloyl dichloride 
• 94-09-7 p-aminoethylbenzoate 
• 88-67-5 2-Iodobenzoic acid 
• 609-67-6 2-Iodobenzoyl chloride 
• 64-18-6 formic acid 
• 64-17-5 ethanol 
• 5383-82-4 4-phthalimidobenzoic acid 
• 85-44-9 phthalic anhydride 

Downstream Products

• 1336907-97-1 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N'-[(4-hydroxyphenyl)methylene]benzohydrazide 
• 1336907-99-3 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N'-(3,4-dimethoxyphenyl)methylenebenzohydrazide 
• 1336908-01-0 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N'-(3-nitrophenyl)methylenebenzohydrazide 
• 1345162-52-8 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N'-(2-hydroxyphenyl)methylenebenzohydrazide 
• 1336908-03-2 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N'-1-(4-hydroxyphenyl)ethylidenebenzohydrazide 
• 1336908-04-3 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N'-1-(4-methylphenyl)ethylidenebenzohydrazide 
• 1336908-05-4 N'-1-(4-chlorophenyl)ethylidene-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzohydrazide 
• 1336908-06-5 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N'-1-(4-nitrophenyl)ethylidenebenzohydrazide 
• 1336908-07-6 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N'-1-(4-methoxyphenyl)ethylidenebenzohydrazide 
• 1336908-08-7 N'-1-(2,4-dichlorophenyl)ethylidene-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzohydrazide 
• 1336908-09-8 N'-1-(2-hydroxy-3-methoxyphenyl)ethylidene-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzohydrazide 
• 1336908-10-1 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N'-1-(2-nitrophenyl)ethylidenebenzohydrazide 
• 106075-43-8 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzohydrazide 
• 109621-43-4 ethyl 4-(1-oxoisoindolin-2-yl)benzoate 

Relevant articles and documents

Electroselective and Controlled Reduction of Cyclic Imides to Hydroxylactams and Lactams

An efficient and practical electrochemical method for selective reduction of cyclic imides has been developed using a simple undivided cell with carbon electrodes at room temperature. The reaction provides a useful strategy for the rapid synthesis of hydroxylactams and lactams in a controllable manner, which is tuned by electric current and reaction time, and exhibits broad substrate scope and high functional group tolerance even to reduction-sensitive moieties. Initial mechanistic studies suggest that the approach heavily relies on the utilization of amines (e.g., i-Pr2NH), which are able to generate α-aminoalkyl radicals. This protocol provides an efficient route for the cleavage of C-O bonds under mild conditions with high chemoselectivity.

PPh3/I2/HCOOH: An efficient CO source for the synthesis of phthalimides

A straightforward and general method has been developed for the synthesis of phthalimide derivatives from 2-iodobenzamides and PPh3/I2/HCOOH in the presence of a catalytic amount of Pd(OAc)2. The reaction results demonstrate that PPh3/I2/HCOOH is a facile, efficient and safe CO source. The whole process is carried out in toluene at 80 °C and furnishes the desired products in good to excellent yields.

Synthesis, characterization and in vivo anticonvulsant and neurotoxicity screening of Schiff bases of phthalimide

A series of Schiff bases of phthalimide (4a-l) were prepared in satisfactory yields and evaluated for their anticonvulsant and neurotoxicity activities. The structures of all the compounds were in good agreement with elemental analysis and spectral data. All the compounds were active in MES screen and less neurotoxic than phenytoin. Compound 4l having nitro substitution at ortho position of the distal aryl ring emerged as most promising anticonvulsant agent with low neurotoxicity.