13089-77-5Relevant articles and documents
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Els et al.
, p. 3777,3781 (1958)
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Two new pregnane steroidal glycosides from Cynanchum taihangense
Wang, Yu-Bo,Su, Shan-Shan,Tang, Ming-Xu,Zhao, Dan,Chen, Gang,Chen, Shao-Fei,Wang, Hai-Feng,Pei, Yue-Hu
, p. 2308 - 2314 (2019/11/03)
As our ongoing chemical investigation, two new pregnane steroidal glycosides, cynataihosides G (1), with a new aglycone, and H (2) were isolated from the 95% ethanol extract of Cynanchum taihangense. Their structures were elucidated on the basis of 1 D and 2 D NMR spectral data, HR-ESI-MS analysis and qualitative chemical methods. The compounds were subjected to detect the cytotoxicity against three human tumor cell lines (HL-60, THP-1 and PC-3). The compounds displayed no significant cytotoxicity. Supplemental data for this article can be accessed at https://doi.org/10.1080/14786419.2019.1672682.
Cytotoxic and apoptosis-inducing activity of C21 steroids from the roots of Cynanchum atratum
Zhang, Jian,Ma, Lin,Wu, Zheng-Feng,Yu, Shu-Le,Wang, Lei,Ye, Wen-Cai,Zhang, Qing-Wen,Yin, Zhi-Qi
, p. 1 - 8 (2017/03/29)
Two new (1–2) and two known C21 steroids (3–4) were isolated from the roots of Cynanchum atratum. Their structures were elucidated by detailed 1D and 2D spectroscopic. The MTT assay showed that compounds 1–4 displayed obvious cytotoxic activities against HepG2 cells with IC50 values ranging from 10.19?μM to 76.12?μM. Compounds 1–3 also exhibited cytotoxic effects in A549 cells with IC50 values of 30.87–95.39?μM. Compound 3 showed the antiproliferative activity via G0/G1 cell cycle arrest and proapoptosis in HepG2 cells by Flowcytometry analysis. Western blotting analysis revealed that compound 3 could induce HepG2 cell apoptosis via the mitochondrial pathway by downregulating Bcl-2 expression, upregulating Bax protein expression, and activating caspase-9 and caspase-3.