130890-78-7

Basic information

• Product Name: DODECYLPHOSPHORYLCHOLINE-D38
• Synonyms: DODECYLPHOSPHOCHOLINE-D38;DODECYLPHOSPHORYLCHOLINE-D38;DODECYLPHOSPHORYLCHOLINE-D38, 98 ATOM % D;12:0 D38 CP
• CAS NO: 130890-78-7
• Molecular Formula: C17D38NO4P
• Molecular Weight: 389.7
• Mol File: 130890-78-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 247-249 °C(lit.)
• Appearance: /
• Storage Temp.: -20°C
• CAS DataBase Reference: DODECYLPHOSPHORYLCHOLINE-D38(CAS DataBase Reference)
• NIST Chemistry Reference: DODECYLPHOSPHORYLCHOLINE-D38(130890-78-7)
• EPA Substance Registry System: DODECYLPHOSPHORYLCHOLINE-D38(130890-78-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 130890-78-7(Hazardous Substances Data)

Usage

Description

Dodecylphosphocholine-d38, also known as MAPCHO?-12-d38, is a detergent intended for use as an internal standard for the quantification of dodecylphosphocholine by gas chromatography (GC) or liquid chromatography (LC) mass spectrometry (MS). It is commonly utilized in the preparation of drug complexes and plays a significant role in various scientific applications, such as membrane protein structure determination, generation of membrane mimetic micelles, and characterization of pore formation by the influenza M2 transmembrane domain within a synthetic membrane. Additionally, dodecylphosphocholine micelles have been found to induce amyloid fibril formation by the prion protein (PrP) β-strand (PrP (110-136)). It has a critical micelle concentration (CMC) of approximately 1.5 mM.

Uses

Used in Pharmaceutical Research:
Dodecylphosphocholine-d38 is used as an internal standard for the quantification of dodecylphosphocholine, which is essential in the study and analysis of membrane proteins. This application aids in the accurate measurement and understanding of the protein's structure and function, contributing to the development of new drugs and therapies.
Used in Nuclear Magnetic Resonance (NMR) Spectroscopy:
In the field of NMR spectroscopy, dodecylphosphocholine-d38 is used as a sample to prepare drug complexes. This application is crucial for determining the structure and dynamics of membrane proteins, which are vital for understanding their biological functions and interactions with other molecules.
Used in Membrane Biophysics:
Dodecylphosphocholine-d38 is used as a detergent to generate membrane mimetic micelles, which are essential for studying the behavior and properties of biological membranes. These micelles help researchers understand the interactions between membrane proteins and other molecules, as well as the structural changes that occur within the membrane.
Used in Structural Biology:
Dodecylphosphocholine-d38 is employed in the characterization of pore formation by the influenza M2 transmembrane domain within a synthetic membrane. This application is vital for understanding the mechanisms of viral infection and the development of antiviral drugs.
Used in Prion Disease Research:
Dodecylphosphocholine-d38 is used to induce amyloid fibril formation by the prion protein (PrP) β-strand (PrP (110-136)). This application is crucial for studying the molecular basis of prion diseases and the development of therapeutic strategies to combat these conditions.