1309235-30-0

Basic information

• Product Name: C₃₆H₃₇N₃O₁₂S
• CAS NO: 1309235-30-0
• Molecular Weight: 735.769
• Mol File: 1309235-30-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₆H₃₇N₃O₁₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₆H₃₇N₃O₁₂S(1309235-30-0)
• EPA Substance Registry System: C₃₆H₃₇N₃O₁₂S(1309235-30-0)

Safety Data

• Hazardous Substances Data: 1309235-30-0(Hazardous Substances Data)

Upstream product

• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 6957-27-3 3,4-dihydropapaverine 
• 139-76-4 N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide 
• 1236876-86-0 4-((4-((3-carboxypropanoyl)oxy)but-2-yn-1-yl)oxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole-2-oxide 
• 13074-31-2 Tetrahydropapaverine 
• 452095-56-6 4-((4-hydroxybut-2-yn-1-yl)oxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 

Relevant articles and documents

Synthesis and evaluation of furoxan-based nitric oxide-releasing derivatives of tetrahydroisoquinoline as anticancer and multidrug resistance reversal agents

Multidrug resistance in tumor cells poses a major obstacle to efficient chemotherapy. Several types of agents have been recognized as multidrug resistance inhibitors, among which the tetrahydroisoquinolines is the most studied. In current study 16 furoxan-based nitric oxide-releasing derivatives of tetrahydroisoquinoline were synthesized. Their cytotoxic activities and effects in reversing multidrug resistance have been evaluated. The results revealed that these compounds had moderate cytotoxic effects. Compounds 7a-f, 7h, and 7l showed higher cytotoxicities than the rest, but lower than adriamycin on K562 cell line. Compounds 7d, 7f, and 7l exhibited potent MDR reversal activities on K562/A02 cell line. The accumulation assay indicated that compounds 7d, 7f, and 7l significantly increased the intracellular accumulation of rhodamine123 in K562/A02 cells. Furthermore, these three compounds produced high concentrations of NO in K562/A02 cells. Potentially, the high concentrations of NO produced by NO donor moieties will lead to an increased cytotoxicity to K562/A02 cells. Our results suggested that compounds 7d, 7f, and 7l had anticancer effects, as well as multidrug resistance reversal effects.