1309439-45-9

Basic information

• Product Name: methyl 4-(3-chloro-2-fluorobenzyl)piperazine-1-carboxylate
• Synonyms: methyl 4-(3-chloro-2-fluorobenzyl)piperazine-1-carboxylate
• CAS NO: 1309439-45-9
• Molecular Weight: 286.734
• Mol File: 1309439-45-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 4-(3-chloro-2-fluorobenzyl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(3-chloro-2-fluorobenzyl)piperazine-1-carboxylate(1309439-45-9)
• EPA Substance Registry System: methyl 4-(3-chloro-2-fluorobenzyl)piperazine-1-carboxylate(1309439-45-9)

Safety Data

• Hazardous Substances Data: 1309439-45-9(Hazardous Substances Data)

Upstream product

• 85070-47-9 1-(bromomethyl)-3-chloro-2-fluorobenzene 
• 50606-31-0 methyl piperazine-1-carboxylate 

Downstream Products

• 873697-71-3 methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate 

Relevant articles and documents

Palladium-catalyzed cross-coupling of aryl chlorides and triflates with sodium cyanate: A practical synthesis of unsymmetrical ureas

An efficient method for palladium-catalyzed cross-coupling of aryl chlorides and triflates with sodium cyanate is reported. The protocol allows for the synthesis of unsymmetrical N,N'-di- and N,N,N'-trisubstituted ureas in one pot and is tolerant of a wide range of functional groups. Insight into the mechanism of aryl isocyanate formation was gleaned through studies of the transmetalation and reductive elimination steps of the reaction, including the first demonstration of reductive elimination from an arylpalladium isocyanate complex to produce an aryl isocyanate.